高密度脂蛋白受体——清道夫受体BⅠ在脓毒症中的作用

Role of high-density lipoprotein receptor-scavenger receptor class B type Ⅰ in sepsis

高密度脂蛋白胆固醇(HDL-C)水平降低被认为与冠状动脉粥样硬化性心脏病(冠心病)的发生密切相关,其主要机制是高密度脂蛋白(HDL)水平降低导致胆固醇逆向转运的障碍。清道夫受体BⅠ(SR-BⅠ)是HDL的受体,在胆固醇转运过程中起到了关键性作用。近年来研究发现,SR-BⅠ在脓毒症中起保护作用,脓毒症病程中的炎症反应、内皮细胞损伤与动脉粥样硬化发生的内皮损伤和炎症过程有着相似的调节机制。本文对SR-BⅠ在脓毒症中的作用进行了综述,以期对动脉粥样硬化等心血管病的机制研究有启示作用。

Low high-density lipoprotein(HDL) contributes to the occurrence of coronary heart disease, partly due to a decrease in HDL-mediated reverse cholesterol transport. Scavenger receptor class type BⅠ(SR-BⅠ) is a HDL receptor which plays a key role in mediating HDL cholesterol transport. Recent studies have found that SR-BⅠ played a very important protective role in sepsis. We summarize the role of SR-BⅠ in sepsis which may provide insight into the study of coronary heart disease, considering that the similarity in inflammatory response between coronary heart disease and sepsis.