老年2型糖尿病微血管病变相关危险因素分析

Analysis of risk factors related to microvascular complications in type 2 diabetes

目的本研究旨在探讨老年2型糖尿病微血管病变相关危险因素。方法收集520例符合条件的老年2型糖尿病患者的临床相关信息,根据有无糖尿病微血管病变分为糖尿病性微血管病变组和无糖尿病性微血管病变组,收集两组一般情况、相关血液学指标及并发症情况。结果在单因素分析中,性别、年龄、糖尿病病程、吸烟史、HbA1c、TG、LDL-C、高血压病有统计学差异(P<0.05)。将单因素分析中有统计学差异的相关指标,包括性别、年龄、糖尿病病程、吸烟史、HbA1c、TG、LDL-C、高血压病纳入多因素Logistic分析模型中,结果显示:糖尿病病程、HbA1c、TG、LDL-C有统计学意义(P<0.05)。即老年2型糖尿病微血管病变与糖尿病病程(OR=1.063,95%CI 1.030~1.096,P=0.000),HbA1c(OR=1.086,95%CI 1.037~1.124,P=0.013),TG(OR=1.152,95%CI 1.046~1.267,P=0.005),LDL-C(OR=1.218,95%CI 1.024~1.610,P=0.028)风险增加相关。结论糖尿病病程、HbA1c、TG、LDL-C为老年2型糖尿病微血管病变的独立危险因素以预测其发生发展。

Objective This study aimed to investigate the risk factors associated with microvascular complications in elderly type 2 diabetes.Methods We recruited 520 elderly patients with T2DM.Based on the presence of microvascular complications,the patients were divided into groups with and without microvascular complications.Collect general conditions,relevant hematology indicators and complications.Results In univariate analysis,gender,age,duration of DM,smoking history,HbA1c,TG,LDL-C,and hypertension were statistically significant(P<0.05).In the multivariate logistic regression analysis,the results showed that duration of DM,HbA1c,TG,and LDL-C were statistically significant(P<0.05).Namely,type 2 diabetic microvascular complications were associated with an increased risk of the duration of DM(OR=1.063,95%CI 1.030~1.096,P=0.000),HbA1c(OR=1.086,95%CI 1.037~1.124,P=0.013),TG(OR=1.152,95%CI 1.046~1.267,P=0.005),LDL-C(OR=1.218,95%CI 1.024~1.610,P=0.028)in elderly T2DM.Conclusion In the elderly,the duration of DM,HbA1c,TG and LDL-C are independent risk factors for type 2 diabetic microvascular complications in order to predict its occurrence and development.