硫辛酸联合前列地尔治疗糖尿病周围神经病变疗效观察

Therapeutic Effect of Lipoic Acid Combined with Alprostadil on Diabetic Peripheral Neuropathy

目的探究硫辛酸注射液与前列地尔治疗糖尿病周围神经病变(DPN)患者的疗效及对血清氧化应激因子的影响。方法纳入我院72例DPN患者进行研究,采用随机数字表法将受试者随机分为实验组(硫辛酸联合前列地尔治疗组)和对照组(前列地尔治疗组)各36例。比较两组患者治疗14 d后临床疗效,以及治疗前、治疗14 d后神级病变程度(TCSS)评分和血清氧化应激因子[超氧化物歧化酶(SOD)、丙二醛(MDA)]水平变化。结果治疗14 d后,实验组治疗总有效率高于对照组(P<0.05),两组患者TCSS评分均较治疗前降低(P<0.05),且实验组治疗后明显低于对照组(P<0.05),两组患者血清SOD、MDA水平均较治疗前降低(P<0.05),且实验组明显低于对照组(P均<0.05)。结论应用硫辛酸注射液与前列地尔治疗DNP可进一步增强疗效,改善患者神经功能与氧化应激状态。

Objective To investigate the efficacy of lipoic acid injection and alprostadil in the treatment of diabetic peripheral neuropathy(DPN)and its effect on serum oxidative stress factor.Methods 72 patients with DPN in our hospital were enrolled and randomly divided into the experimental group(lipoic acid combined with alprostadil treatment group)and the control group(alprostadil treatment group),36 cases in each group.The clinical effects of the two groups after 14 days of treatment were compared.The TCSS score before and 14 d after treatment,and the serum oxidative stress factor [superoxide dismutase(SOD),malondialdehyde(MDA)] levels of the two groups were compared.Results After treatment for 14 days,the total effective rate of the experimental group was significantly higher than that of the control group(P<0.05).After 14 days of treatment,the TCSS scores of the two groups were lower than those before treatment(P<0.05),and the experimental group was significantly lower than the control group after treatment(P<0.05).The levels of serum SOD and MDA in the two groups were lower than those before treatment(P<0.05),and the experimental group was significantly lower than the control group(P <0.05).Conclusion The use of lipoic acid injection and alprostadil in the treatment of DNP can further enhance the efficacy and improve the neurological function and oxidative stress in patients.