多烯紫杉醇联合奈达铂同步放化疗治疗局部中晚期食管癌疗效观察

Efficacy of Docetaxel Combined with Neidaplatin in the Treatment of Locally Advanced Esophageal Carcinoma

目的探讨多烯紫杉醇联合奈达铂同步放化疗治疗局部中晚期食管癌的临床效果。方法选取2016年1月至2017年12月我院收治的局部中晚期食管癌患者共计80例,随机分为对照组和观察组各40例。对照组给予顺铂+多烯紫杉醇化疗,观察组给予多烯紫杉醇+奈达铂化疗,比较临床疗效。结果观察组随访1年的生存率明显高于对照组,不良反应明显高于对照组(P<0.05)。结论局部中晚期食管癌患者给予多烯紫杉醇联合奈达铂同步放化疗治疗,能明显提升患者生存率,并且降低不良反应。

Objective To investigate the clinical efficacy of paclitaxel combined with nedaplatin in concurrent radiotherapy and chemotherapy for locally advanced esophageal cancer.Methods A total of 80 patients with locally advanced esophageal cancer admitted to our hospital from January 2016 to December 2017 were selected and randomly divided into control group and observation group with 40 cases each.The control group was treated with cisplatin+docetaxel chemotherapy,while the observation group was treated with docetaxel+nedaplatin chemotherapy,and the clinical efficacy was compared.Results The survival rate of the observation group was significantly higher than that of the control group after 1 year follow-up,and the adverse reactions were significantly higher than those of the control group(P<0.05).Conclusion The concurrent chemoradiotherapy with paclitaxel and nedaplatin in patients with locally advanced esophageal cancer can significantly improve the survival rate of patients and reduce adverse reactions.