摘要
肝移植是治疗终末期肝病的有效方法,然而供器官来源紧缺限制了肝移植的发展,因此亟需找到其他有效可行的治疗措施。干细胞具有良好的自我更新和分化潜能,具有修复受损肝脏的潜力。本文综述间充质干细胞的来源、生物学特性和免疫调节作用以及治疗终末期肝病的前景、机制及其临床应用。
Liver transplantation is an effective therapy method for end-stage liver disease.However,the shortage of donor organs restricts the development of liver transplantation,and we urgently need to find other effective and feasible treatment measures.Mesenchymal stem cells(MSCs)have both the capacity for self-renewal and the potential for differentiation,and research has shown that they also had the potential to repair damaged liver.In this paper,the source,biological characteristics,immunoregulation and treatment prospects for end-stage liver disease of MSCs are briefly reviewed.
作者
柳安雄
王伟
钟自彪
叶啟发
Liu Anxiong;Wang Wei;Zhong Zibiao;Ye Qifa(Zhongnan Hospital of Wuhan University,Institute of Hepatobiliary Diseases of Wuhan University,Transplant Center of Wuhan University,Hubei Key Laboratory of Medical Technology on Transplantation,Wuhan 430071,China;The 3rd Xiangya Hospital of Central South University,Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology,Changsha 410013,China)
出处
《中华移植杂志（电子版）》
CAS
2020年第1期49-53,共5页
Chinese Journal of Transplantation(Electronic Edition)
基金
国家自然科学基金-新疆联合基金(U1403222)。
关键词
间充质干细胞
终末期肝病
免疫调节
干细胞移植
Mesenchymal stem cells
End-stage liver disease
Immunoregulation
Stem cell transplantation
