摘要
对盐酸吉西他滨粗品合成过程及其影响因素进行了探讨,研究发现,CH3OH的加入量为中间体用量的4倍,反应时间为20h,反应温度控制在85℃,反应体系pH值为2时,产品产率最高。
The synthetic process and influencing factors of crude gemcitabine hydrochloride were discussed.It was found that when the added amount of CH3OH was 4 times of the intermediate,the reaction time was 20 h,the reaction temperature was controlled at 85℃,and the pH of the reaction system was 2,the product yield was the highest.
作者
胡娜
杭彩云
陈波
Hu Na;Hang Caiyun;Chen Bo(Jiangnan University, Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, Wuxi 214122, Jiangsu, China;Amcor Flexibles Jiangyin. Propack Packing Co., Ltd., Jiangyin 214433, Jiangsu, China;Chemical Textile Engineering, Jiangyin Polytechnic College, Jiangyin 214405, Jiangsu, China)
出处
《四川化工》
CAS
2020年第2期14-16,共3页
Sichuan Chemical Industry
基金
2019年江苏省高校“青蓝工程”项目
2019年度江苏省博士后科研资助计划
江苏省高校哲学社会科学研究项目(2017SJB0875)。
关键词
盐酸吉西他滨
粗品
影响因素
influencing factors
crude
gemcitabine hydrochloride
