蛋白质残基相互作用网络在线服务及可视化分析

Aweb server for protein network analysis and visualization

蛋白质残基相互作用网络对理解蛋白质的结构特征,生物学功能和结合位点预测等研究有重要的作用.然而,现有的蛋白质残基相互作用分析方法易用性较差,需要下载和安装程序,较少提供友好易用的网络可视化功能,极大限制了蛋白质结构、功能和药物设计的相关研究.建立了蛋白质残基相互作用网络在线服务及可视化计算平台(http://renault.fun),用户不需要下载和编写程序,仅需上传蛋白质结构数据和口袋相关信息即可搭建蛋白质残基相互作用网络,并实现度中心度(degree centrality),接近中心度(closeness centrality)和中介中心度(betweenness centrality)等网络特征的计算.该计算平台可进一步实现蛋白质残基相互作用网络的可视化,分析蛋白质表面结合口袋的网络特性,对理解蛋白质结构和药物设计的相关应用研究有较大的帮助.

The protein residue-residue interaction network plays an important role in structural characteristics analysis,protein function prediction,and drug design.However,the existing methods are very difficult to use.Biologists need to download and install the programs locally.Besides,the lacking of network visualization limited the application.In this paper,we provide a web server for protein network analysis and visualization(http://renault.fun).Users can upload the protein structural information and submit the analysis job online.Then,the web server is able to transform the structural information into a network and calculate the network centrality values,such as closeness centrality and betweenness centrality.Moreover,this web server also provides the network and protein structural visualization for detail characteristics analysis.The protein network analysis web server is a user-friendly web server and helpful to the applications of protein structure-function understanding and drug design.