长链非编码RNA MALAT1与前列腺癌的关系

Relationship between long non-coding RNA MALAT1 and prostate cancer

前列腺癌通常是指前列腺腺泡上皮来源的恶性肿瘤,已成为威胁老年男性健康的全球性“杀手”.前列腺癌的进展机制以及治疗策略一直是研究的重点,近年来,长链非编码RNA似乎在这当中发挥重要的作用.长链非编码RNA MALAT1在前列腺癌进展、治疗中发挥关键的作用,其不仅影响前列腺癌生物学特性,在肿瘤转移、侵袭、细胞增殖等方面都起到关键的作用,而且在肿瘤药物治疗中起到调节作用,其作用机制与ceRNA、AR信号通路等有关.本文就长链非编码RNA MALAT1与前列腺癌的关系作一综述,希望能为前列腺癌的诊治提供新的研究方向.

Prostate cancer(PCa),as a malignant tumor originating in the prostate glandular epithelium,has become a global"killer"that threatens the health of elderly men.PCa-related studies have been focusing on the progression mechanisms and treatment strategies of the malignancy,particularly on the role of long non-coding RNA(lncRNA)in recent years.The lncRNA metastasis-associated lung adenocarcinoma transcript 1(MALAT1)plays a key role in the progression and treatment of PCa,as well as in its metastasis and invasion and cell proliferation.lncRNA MALAT1 not only influences the biological characteristics of PCa,but also has a regulatory effect on the medicinal treatment of the disease,its action mechanisms involving ceRNA and AR signaling pathways.This review focuses on the relationship between lncRNA MALAT1 and PCa,aiming to provide a new research direction for the diagnosis and treatment of the malignancy.