不平“钒”的金属元素

Vanadium: An Unusual Metal Element

钒是地壳中含量第21丰富元素,是人体必需的微量元素。介绍钒元素的发现、自然分布以及在人体内的循环。重点从化学结构分析钒酸盐-磷酸盐的拮抗作用机制,从生化机理阐述钒化合物对激酶与磷酸酶的调节、对RNA和DNA功能的影响、对活性氧作用的影响,从人体健康视角探讨钒对治疗糖尿病和癌症及保护心血管等的潜在药理学作用。

Vanadium is the 21st richest element in the Earth’s crust and is an essential trace element for human body. This article describes the discovery, natural distribution, and circulation of vanadium in the human body. It sheds light on the vanadate-phosphate antagonism mechanism by studying the chemical structure. From the angle of biochemical mechanism, the article explains the regulation of vanadium compounds on kinases and phosphatases, and their influence on RNA and DNA function and reactive oxygen species. It also explores the potential pharmacological effects on the treatment of diabetes, cancer, and cardiovascular protection from the perspective of human health.