稳定期精神分裂症患者血浆炎症因子与症状相关性研究

Research on the Relationship between Serum Inflammatory Factors and Clinical Symptoms in Patients with Stable Schizophrenia

目的探讨稳定期精神分裂症患者血浆炎症因子水平及其与临床症状的关系。方法纳入稳定期精神分裂症患者75例(研究组)和健康对照40名(对照组),采用流式多重蛋白分析技术(cytometric bead array,CBA)检测所有被试的血浆促炎因子肿瘤坏死因子α(tumor necrosis factorα,TNF-α)和抗炎因子白介素10(interleukin 10,IL-10)浓度,采用阳性与阴性症状量表(positive and negative symptom scale,PANSS)评估患者临床症状。结果研究组与对照组的促炎因子TNF-α浓度差异有统计学意义[中位数与上下四分位数:1.16(1.02,1.49)ng/L vs.0.67(0.61,0.76)ng/L,P<0.01],IL-10浓度差异无统计学意义(P>0.05)。偏相关分析示,研究组血浆TNF-α浓度与PANSS中反应缺乏因子(r′=-0.33,P=0.01)、偏执因子(r′=-0.32,P=0.01)之间呈负相关。结论稳定期精神分裂症患者血浆TNF-α水平高于正常对照水平,且患者TNF-α水平与临床症状严重程度存在一定联系。

Objective To explore the relationship between serum inflammatory factors and clinical symptoms in patients with stable schizophrenia.Methods Seventy-five patients with stable schizophrenia(research group)and 40 healthy controls(control group)were enrolled.Serum pro-inflammatory factor tumor necrosis factorα(TNF-α)and anti-inflammatory factor interleukin 10(IL-10)concentrations were measured by flow cytometry and clinical symptoms were evaluated by positive and negative symptom scale(PANSS).Results There was a significant difference in serum proinflammatory cytokines TNF-αbetween the research group and the control group[the median and lower and upper quartile:1.16(1.02,1.49)ng/L vs.0.67(0.61,0.76)ng/L,P<0.01].Partial correlation analysis showed that TNF-αwere negatively correlated with reaction deficiency factor(r′=-0.33,P=0.01)and paranoid factor(r′=-0.32,P=0.01)in the research group.Conclusion The level of serum TNF-αwas higher in stable schizophrenia than in normal subjects and the level of serum TNF-αis associated with the severity of clinical symptoms.