以中药泡洗为主治疗脑卒中后肩手综合征疗效的Meta分析

Effect of Chinese herbal soaking on the shoulder-hand syndrome in patients after stroke:a Meta-analysis

[目的]评价以中药泡洗为主治疗脑卒中后肩手综合征的临床疗效。[方法]计算机检索中国学术期刊全文数据库(CNKI)、万方数据库、维普科技期刊全文数据库(VIP)和中国生物医学数据库(CBM),纳入中药泡洗治疗脑卒中后肩手综合征的临床随机对照试验。由2名研究者独立提取资料并按照Cochrane Handbook 5.1.0进行质量评价,采用RevMan 5.3软件进行统计分析。[结果]共纳入12篇随机对照试验,共有1180例病人。Meta分析结果显示:试验组在治疗脑卒中后肩手综合征有较好的临床疗效[OR=3.72,95%CI(2.61,5.30),P<0.00001],能缓解肩手综合征的疼痛[MD=-1.55,95%CI(-1.80,-1.30),P<0.00001];可改善病人的上肢功能[MD=7.58,95%CI(5.65,9.51),P<0.00001];可提高病人的生活质量[MD=33.87,95%CI(16.67,51.08),P=0.0001]。[结论]现有数据表明,以中药泡洗为主对肩手综合征有一定的疗效,能缓解脑卒中后肩手综合征的疼痛,改善病人的上肢功能和生活质量,但仍需要多中心、大样本、质量高的临床随机对照试验对研究结论提供进一步的支持。

Objective:To evaluate the clinical efficacy of Chinese herbal soaking on the shoulder-hand syndrome in patients after stroke.Methods:The clinical randomized controlled trials(RCTs)on the application of Chinese herbal soaking in the shoulder-hand syndrome in patients after stroke,were retrieved from China National Knowledge Infrastructure(CNKI),WanFang database,VIP Database,and Chinese Biomedical Database(CBM).Data was extracted by two researchers independently.According to Cochrane Handbook 5.1.0,quality evaluation was conducted.And software RevMan5.3 was used to take a statistical analysis.Results:A total of 12 RCTs were included,involving 1180 patients.Meta-analysis showed that clinical efficacy on treating of shoulder-hand syndrome after stroke in the experimental group was better[OR=3.72,95%CI(2.61,5.30),P<0.00001].Chinese herbal soaking could relieve the pain of shoulder-hand syndrome[MD=-1.55,95%CI(-1.80,-1.30),P<0.00001],enhance the function of upper extremity[MD=7.58,95%CI(5.65,9.51)P<0.00001],and improve the quality of life of patients after stroke[MD=33.87,95%CI(16.67,51.08),P=0.0001].Conclusions:Existing data showed that Chinese herbal soaking had a certain effect on the shoulder-hand syndrome in patients after stroke,which could relieve the pain of shoulder-hand syndrome after stroke,improve the function of upper extremity and quality of life.However,there still needs to be multi-center,large-sample,and high-quality RCTs to provide further support for the research conclusions.