探讨中晚期宫颈癌患者同步放化疗与单纯放射治疗的临床疗效及不良反应

To Explore the Clinical Effects and Adverse Reactions of Concurrent Radiotherapy and Chemotherapy and Radiation Therapy Alone in Patients with Advanced Cervical Cancer

目的探讨中晚期宫颈癌患者同步放化疗与单纯放射治疗的临床疗效及不良反应。方法纳入2009年1月至2017年1月这个时间段中入住我院的中晚期宫颈癌患者总计56例,按照患者的入院顺序给予前28例患者单纯放射疗法并划分为对照组,剩余28例入院时间较晚的患者则接受同步放化疗,将其划分为观察组,记录两种治疗方法下患者的病情改善情况以及出现不良反应的情况,综合分析不同治疗方法的应用效果。结果①观察组中疗效评定结果为显效以及有效的患者明显多于对照组(P<0.05)。②治疗结束后对患者随访至今,观察组患者1年内、2年内的生存质量均明显高于对照组(P<0.05)。③观察组内出现不良病症的患者明显多于对照组(P<0.05),但不良病症均处于患者耐受范围内。结论中晚期宫颈癌患者的治疗中选用同步放化疗能够有效改善患者的病情,延长患者的生存时间,所引发的不良反应均处于患者耐受范围内,综合应用价值与单纯放射疗法进行比较具有明显优势,值得推荐使用。

Objective To investigate the clinical effi cacy and adverse reactions of concurrent radiotherapy and chemotherapy alone in patients with advanced cervical cancer.Methods A total of 56 patients with advanced cervical cancer admitted to our hospital from January 2009 to January 2017 were enrolled.The fi rst 28 patients were treated with radiotherapy alone and divided into control group according to the order of admission.The remaining 28 patients were treated with concurrent radiotherapy and chemotherapy.The patients were divided into two groups.The improvement of patients'condition and the adverse reactions were recorded under the two treatment methods.The effects of different treatment methods were analyzed synthetically.Results(1)In the observation group,the effective and effective patients were signifi cantly more than those in the control group(P<0.05).(2)The patients in the observation group were followed up until now,and the patients in the observation group were within one year.The quality of life(QOL)in two years was signifi cantly higher than that in control group(P<0.05).(3)The number of patients with adverse disease in the observation group was signifi cantly higher than that in the control group(P<0.05),but the adverse symptoms were within the range of patient tolerance.Conclusion simultaneous radiotherapy and chemotherapy in the treatment of advanced cervical cancer can effectively improve the patient's condition,prolong the patient's survival time,and cause adverse reactions within the range of patient tolerance.Application value compared with radiotherapy alone has obvious advantages and is worthy of recommendation.