表皮生长因子对动物肠道黏蛋白分泌的影响及其作用机制

Effects of Epidermal Growth Factor on Intestinal Mucin Secretion and Its Action Mechanism

表皮生长因子(epidermal growth factor,EGF)是一种含有53个氨基酸残基的小分子肽,在黏膜屏障功能的维持与修复中发挥重要作用。黏液层是动物肠道的第一道屏障,可阻止有害菌的入侵,同时也是机体与外部环境交换营养物质、水、气体等物质的重要场所。黏蛋白(mucins,MUCs)是黏液层的主要成分,它是一种相对分子质量较高的糖蛋白。EGF可通过刺激肠道杯状细胞的增殖促进黏蛋白的分泌以维持肠道黏液的不断更新。本文主要综述了黏蛋白的结构和功能以及EGF对肠道黏蛋白分泌的影响及其调控作用机制,以期为EGF在动物肠道健康调节中的作用提供参考。

Epidermal growth factor(EGF)is a small peptide containing 53 amino acid residues,which plays an important role in the maintenance of mucosal barrier function and intestinal repair.Mucous layer is the first barrier of animal intestines,which can prevent harmful bacteria from invading the body.Meanwhile,mucous layer is also an important place where nutrients,water,gas and other substances exchange with the external environment.Mucins(MUCs)are the main component of mucous layer,and a kind of glycoproteins with relatively high molecular mass.EGF can promote the secretion of mucin by stimulating the proliferation of intestinal goblet cells to maintain the constant replacement of intestinal mucus.The structure and function of mucins,the effect of EGF on intestinal mucin secretion and its regulatory mechanism were reviewed to provide some references for studying EGF functions in animal intestinal health regulation.