长链多不饱和脂肪酸结构脂合成方法及影响因素研究进展

Advances of the synthesis of structural lipid with long-chain polyunsaturated fatty acid esters as acyl donor and its influencing factors

结构脂质在提高免疫力、预防肥胖、癌症和缓解营养障碍等方面具有显著的优势,这与其结构上连接的功能性脂肪酸有密切联系。结构脂质在结构上的差异不仅包含接入甘油三酯骨架上脂肪酸的不同种类,也包含由脂肪酸在甘油骨架上的随机/选择性定位效应。长链多不饱和脂肪酸MLM型结构脂是结构脂最理想的结构形式,该文针对长链多不饱和脂肪酸结构脂的合成方法进行了综述,并分类介绍了相关产物合成影响因素的最新研究进展,以期为相关sn-2长链多不饱和脂肪酸功能性结构脂的制备和改性研究提供参考。

Structural lipids have significant advantages in improving immunity,preventing obesity,cancer and alleviating nutritional disorders,which are closely related to structurally linked functional fatty acids.The structural differences in lipids include not only different types of fatty acids incorporated into the triglyceride skeleton but also the random/selective localization effect of fatty acids on the glycerol skeleton.MLM structural lipids of long-chain polyunsaturated fatty acids are ideal structural lipids.This paper reviewed the recent progress in the synthesis of long-chain polyunsaturated fatty acid esters and the factors that influence the synthesis of the products so as to provide references for the preparation of related functional structural lipids of long-chain polyunsaturated fatty acids.