糖尿病足溃疡病原菌分布及耐药性分析

Analysis of distribution and drug resistance of pathogenic bacteria in diabetic foot ulcer

目的分析糖尿病足溃疡病原菌分布及耐药性。方法选择2015年12月-2019年1月于青岛大学医学院附属威海医院/威海市立第二医院治疗的糖尿病足溃疡患者200例,对溃疡部位的分泌物进行分离,测定其菌株及耐药性。结果 200例患者中培养出病原菌株的患者180例,培养出菌株215株,其中革兰阳性球菌120株,革兰阴性杆菌76株,真菌19株;对培养出的菌株进行耐药性分析,革兰阳性球菌及革兰阴性杆菌对头孢类抗菌药物、阿莫西林、四环素等有一定耐药性,对莫西沙星、庆大霉素的敏感性较好。结论糖尿病足溃疡病原菌以革兰阳性球菌为主,且具有一定的耐药性,临床应配合耐药性监测结果选择抗生素治疗。

Objective To analyze the distribution and drug resistance of pathogenic bacteria in diabetic foot ulcers.Methods 200 patients with diabetic foot ulcer treated in Weihai Hospital Affiliated to Qingdao University School of Medicine/Weihai Municipal Second Hospital from December 2015 to January 2019 were selected. The secretions at the ulcer location were separated and analyzed,and the strains and drug resistance were determined. Results Of the 200 patients,180 were pathogenic strains,215 strains were cultured,of which 120 were Gram-positive cocci strains,76 were Gram-negative strains,and 19 were fungi. Analysis of the resistance of the cultured strains,Gram-positive cocci and Gram-negative bacilli were resistant to cephalosporins, amoxicillin, tetracycline, etc, and sensitive to moxifloxacin and gentamicin better.Conclusion The main pathogens of diabetic foot ulcers are Gram-positive cocci,which have certain drug resistance,and antibiotics should be selected in the clinic in accordance with the results of drug resistance monitoring.