盐酸普萘洛尔治疗肝硬化并发消化道出血患者的临床效果及安全性评价

Evaluation on the Clinical Effect and Safety of Propranolol Hydrochloride in the Treatment of Patients with Liver Cirrhosis Complicated with Gastrointestinal Hemorrhage

目的探讨盐酸普萘洛尔治疗肝硬化并发消化道出血患者的临床效果及安全性。方法选取我院2012年2月至2016年7月收治的肝硬化并发消化道出血患者60例,随机分为两组各30例。观察组给予盐酸普萘洛尔治疗,对照组给予奥曲肽治疗。比较两组的治疗效果、止血情况、血流动力学指标以及不良反应。结果观察组的治疗总有效率为93.33%,显著高于对照组的73.33%(P<0.05)。观察组的心率、中心静脉压、止血时间均显著优于对照组(P<0.05)。治疗后,两组的门静脉血流量、脾静脉血流量均显著降低,且观察组的门静脉血流量、脾静脉血流量均显著低于对照组(P<0.05)。结论盐酸普萘洛尔治疗肝硬化并发消化道出血的疗效显著,能够缩短患者的出血时间,且安全性较高,值得临床应用。

Objective To explore the clinical effect and safety of propranolol hydrochloride in the treatment of patients with liver cirrhosis complicated with gastrointestinal hemorrhage.Methods 60 patients with liver cirrhosis complicated with gastrointestinal hemorrhage admitted to our hospital from February 2012 to July 2016 were selected and randomly divided into two groups,with 30 cases in each group.The observation group was treated with propranolol hydrochloride,and the control group was treated with octreotide.The therapeutic effect,hemostasis,hemodynamic indicators and adverse reactions were compared between two groups.Results The total effective rate of treatment of observation group was 93.33%,significantly higher than 73.33%of control group(P<0.05).The heart rate,central venous pressure and hemostasis time of observation group were significantly better than those of control group(P<0.05).After treatment,the portal vein blood flow and splenic vein blood flow of two groups reduced significantly,and the portal vein blood flow and splenic vein blood flow of observation group were significantly lower than those of control group(P<0.05).Conclusions Propranolol hydrochloride in the treatment of liver cirrhosis complicated with gastrointestinal hemorrhage has significant efficacy and high safety,which can shorten the hemorrhage time of patients,and is worthy of clinical application.