GnRHa长方案对体外受精-胚胎移植卵巢储备功能减退患者移植结局的影响

Effect of Long GnRHa Protocol on the Transplant Outcomes of IVF-ET Patients with Ovarian Reserve Dysfunction

目的探讨GnRHa长方案对体外受精-胚胎移植(IVF-ET)卵巢储备功能减退患者移植结局的影响。方法120例IVF-ET卵巢储备功能减退患者根据促排卵方案的不同分为两组各60例,GnRHa组行GnRHa长方案进行促排卵,GnRHant组行GnRHant方案进行促排卵,比较两组的相关临床指标及移植结局。结果两组的AFC个数、bFSH水平、AMH水平、胚胎着床率比较,差异无统计学意义(P>0.05)。GnRHa组的HCG注射日子宫内膜厚度显著大于GnRHant组,妊娠率显著高于GnRHant组(P<0.05)。结论IVF-ET卵巢储备功能减退患者采用GnRHa长方案进行促排卵效果较好,可有效提高患者的妊娠率。

Objective To explore the effect of long GnRHa protocol on the transplant outcomes of in vitro fertilization-embryo transfer(IVF-ET)patients with ovarian reserve dysfunction.Methods 120 IVF-ET patients with ovarian reserve dysfunction were equally divided into two groups according to different ovulation induction schedules.The GnRHa group received long GnRHa protocol for ovulation induction,and the GnRHant group received GnRHant protocol for ovulation induction.The related clinical indicators and transplant outcomes were compared between two groups.Results No significant difference was found in the AFC count,bFSH level,AMH level and embryo implantation rate between two groups(P>0.05).The endometrial thickness on the day of HCG injection in the GnRHa group was significantly greater than that in the GnRHant group,and the pregnancy rate was significantly higher than that in the GnRHant group(P<0.05).Conclusions For IVF-ET patients with ovarian reserve dysfunction,long GnRHa protocol for ovulation induction has good effect,and can effectively improve the pregnancy rate of patients.