摘要
Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular organisms.Their regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with age.During aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016).
基金
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010100)
Major Program of Development Fund for Shanghai Zhangjiang National Innovation Demonstration Zone(ZJ2018-ZD-004)
the National Natural Science Foundation of China(81625009,81330008,91749202)
Beijing Municipal Commission of Health and Family Planning(PXM2018_026283_000002)
This study was supported by,Fundaci6n Dr.Pedro Guillen,Universidad Catolica San Antonio de Murcia(UCAM),Asociacion de Futbolistas Espanoles(AFE),Fundacion Telefonica,Fundacion MAPFRE,The Moxie Foundation and The G.Harold and Leila Y.Mathers Charitable Foundation.
