牛疱疹病毒糖蛋白D的结构特点及在疫苗学中的应用

Structural Characteristics and Applications in Vaccinology of Bovine Herpesvirus Glycoprotein D

牛疱疹病毒1型(Bovine Herpesviruses 1,BHV-1)和牛疱疹病毒5型(Bovine Herpesviruses,BHV-5)是引起牛呼吸道疾病的2大重要病原,其膜糖蛋白D(Glycoprotein D,gD)是病毒粒子的重要组成成分,在疱疹病毒的发病机理方面发挥重要作用。该文介绍了BoHV-1、BoHV-5的结构和功能特征,以及它在病毒进入宿主细胞和与宿主细胞受体相互作用中的作用,讨论了gD与宿主免疫系统的相互作用,并结合该蛋白的结构和功能特点,阐述了其在新疫苗设计中的应用。

The viral envelope glycoprotein D from (bovine herpesviruses 1 and 5 BoHV-1 and-5),two important pathogens of cattle,is a major component of the virion and plays a critical role in the pathogenesis of herpesviruses.Glycoprotein D is essential for virus penetration into permissive cells and thus is a major target for virus neutralizing antibodies during infection.This review highlights the structural and functional characteristics of BoHV-1,BoHV-5 and where appropriate,Human herpesvirus gD,as well as its role in viral entry and interactions with host cell recep?tors.Furthermore,the interactions of gD with the host immune system are discussed.Finally,the application of this glycoprotein in new vaccine design is reviewed,taking its structural and functional characteristics into consideration.