慢性肾脏病患者发生动脉粥样硬化的相关危险因素分析

Risk factors of atherosclerosis in patients with chronic renal disease

目的:探讨慢性肾脏病(CKD)患者发生颈动脉内膜中层厚度(IMT)增厚及颈动脉斑块形成的危险因素。方法:选择2016年1月—2017年1月收治的慢性肾脏病且未接受透析治疗的患者50例(观察组)和同期住院的非慢性肾脏病患者50例(对照组),检查血压、总胆固醇、甘油三酯、C反应蛋白、血肌酐、尿素氮、同型半胱氨酸等指标,并做颈动脉超声检查颈动脉内膜中层厚度和粥样斑块。分析影响颈动脉内膜中层厚度的危险因素。结果:慢性肾脏病患者中颈动脉内膜中层厚度明显增厚,动脉斑块发生率高,与血肌酐、血尿素氮、C反应蛋白、同型半胱氨酸呈正相关。结论:血肌酐、血尿素氮、C反应蛋白、同型半胱氨酸是CKD患者发生动脉粥样硬化的独立危险因素。

Objective:To investigate the risk factors of carotid endothelium thickness(IMT)thickening and carotid plaque formation in patients with chronic renal disease(CKD).Methods:All 50 patients with abnormal renal function and 50 patients with healthy control group were examined for blood pressure,total cholesterol,triglyceride,C-reactive protein,blood creatinine,uric acid,homocysteine,etc.,and carotid artery ultrasound was used to examine the middle thickness of carotid endometrium and atherosclerotic plaque.The risk factors affecting the middle thickness of carotid endometrium were analyzed.Results:The thickening of the middle layer of carotid endometrium in patients with chronic renal disease and the high incidence of arterial plaques were positively correlated with blood creatinine,blood uric acid,C-reactive protein and homocysteine.Conclusion:Blood creatinine,blood uric acid,C-reactive protein,homocysteine are independent factors of atherosclerosis in CKD patients.