早发型子痫前期患者维生素A、维生素E、辅助性T细胞水平及相关危险因素分析

Analysis of the levels of vitamin A,vitamin E and helper T cell of women with early-onset preeclampsia and the related risk factors

目的:观察早发型子痫前期(PE)患者维生素A、维生素E及辅助性T细胞的变化,分析相关危险因素。方法:收集2016年12月-2018年5月本院正常妊娠孕妇2650例,早发型子痫前期孕妇350例。取所有孕妇外周静脉血,检测维生素A、维生素E、辅助性T细胞水平,分析可能影响早发型子痫前期因素。结果:子痫前期组孕妇血清维生素A(0.24±0.15mg/L)、维生素E(4.92±2.31mg/L)低于正常组(0.47±0.18mg/L、10.75±4.57 mg/L),血液中Th(21.01±3.96%)、Th1/Th2(20.41±5.75)高于正常组(12.31±2.50%、7.93±1.46),Th2(1.04±0.17%)低于正常组(1.60±0.29%)(均P<0.05)。多胎妊娠、年龄≥35岁、有内科合并症、维生素E缺乏、产前体质指数异常是早发型子痫前期发病的独立危险因素。结论:早发型PE孕妇体内维生素A、维生素E缺乏,且机体免疫平衡出现紊乱,多胎妊娠、年龄≥35、有内科合并症、维生素E缺乏、产前体质指数异常为早发型PE的危险因素,在临床应予以重视。

Objective:To observe the changes of the levels vitamin A,vitamin E and helper T cell of women with early-onset preeclampsia,and to analyze the risk factors related to early-onset preeclampsia.Methods:2,650 normal pregnant women were included in group A between December 2016 and May 2018,which included 350 women with early-onset preeclampsia were included in group B and the other women without preeclampsia were in group A.The levels of vitamin A,vitamin E and helper T cell in peripheral venous blood of women were recorded and compared between the two groups.The suspicious factors affecting the early-onset preeclampsia were analyzed.Results:The levels of serum vitamin A and vitamin E,and the Th2 percentage of women in group B were 0.24±0.15mg/L,4.92±0.18mg/L,and 1.04±0.17%,which were significant lower than those(0.47±0.18mg/L,10.75±4.57mg/L,and 1.60±0.29%)of women in group A,but the Th 1 percentage and Th1/Th2 value of women in group B were 21.01±3.96%and 20.41±5.75,which were significant higher than those(12.31±2.50%and 7.93+1.46)of women in group A(all P<0.05).Multiple pregnancy,age≥35 years old,medical complications,vitamin E deficiency,and prenatal BMI abnormalities were independent risk factors of early-onset preeclampsia.Conclusion:The pregnant women with early-onset preeclampsia lack vitamin A and vitamin E,and have the immune balance disorder.Multiple pregnancy,age≥35 years old,medical complications,lack vitamin E,and abnormal prenatal BMI are independent risk factors of early-onset preeclampsia,so it should be paid more attention in clinic practice.