小剂量阿司匹林联合钙剂、维生素E治疗妊娠期高血压疾病的疗效评价

Efficacy evaluation of low-dose aspirin combined with calcium and vitamin E for treating pregnant women with hypertensive disorder complicating pregnancy

目的:分析小剂量阿司匹林联合钙剂、维生素E治疗妊娠期高血压疾病的疗效及对血清尿酸(UA)、胱抑素C(CysC)水平的影响。方法:选择2016年1月-2018年6月本院收治的160例妊娠期高血压疾病患者,随机分为对照组(n=89)和观察组(n=71),对照组采用硫酸镁治疗,观察组予以小剂量阿司匹林联合钙剂、维生素E治疗,比较两组临床疗效,治疗前后血压、血清钙、UA、CysC水平和妊娠结局。结果:观察组总有效率(93.0%)高于对照组(81.0%)(P<0.05)。治疗后两组舒张压、收缩压、血清UA、CysC水平均下降,观察组下降幅度高于对照组;两组血清钙水平均上升且观察组上升更多(均P<0.05)。观察组早产(1.4%)、剖宫产(29.6%)、产后出血(2.8%)及胎儿生长受限(1.4%)发生比例低于对照组(P<0.05)。结论:小剂量阿司匹林联合钙剂、维生素E能够提高妊娠期高血压疾病患者的血压控制效果,降低血清UA及CysC水平,改善妊娠结局。

Objective:To analyze the efficacy evaluation of low-dose aspirin combined with calcium and vitamin E for treating pregnant women with hypertensive disorder complicating pregnancy,and to study its influence on their serum levels of uric acid(UA)and Cystatin C(CysC).Methods:160 pregnant women with hypertensive disorder complicating pregnancy were included and were divided into the control group(n=89)and observation group(n=71)according to random number table method from January 2016 to June 2018.The women in the control group were treated with magnesium sulfate,and the women in the observation group were treated with low-dose aspirin combined with calcium and vitamin E.The clinical curative effect,blood pressure,serum levels of calcium,UA,and CysC before and after treatment,and the pregnancy outcomes of women were compared between the two groups.Results:The total effective rate of women in the observation group was 93.0%,which was significant higher than that(81.0%)of women in the control group(P<0.05).After treatment,the values of diastolic blood pressure and systolic blood pressure,and the serum UA and CysC levels of women in the two groups had decreased significantly,and which decreased degree of women in the observation group was significant higher than that of women in the control group.After treatment,the serum calcium level of women in the two groups had increased significantly,and which increased degree of women in the observation group was significant higher than that of women in the control group(P<0.05).The incidences of premature delivery,cesarean section,postpartum hemorrhage,and fetal growth restriction of women in the observation group were 1.4%,29.6%,2.8%,and 1.4%,respectively,which were significant lower than those of women in the control group(P<0.05).Conclusion:Low-dose aspirin combined with calcium and vitamin E for treating pregnant women with hypertensive disorder complicating pregnancy can improve their pregnancy outcomes by improving the effect of blood pressure controlled and decreasing the serum levels of UA and CysC of women.