氟比洛芬酯辅助枸橼酸芬太尼用于稽留流产术麻醉效果比较

A comparative study of the anesthesia effect of flurbiprofen axetil combined with fentanyl citrate in missed abortion

目的:观察氟比洛芬酯辅助枸橼酸芬太尼用于稽留流产流产术麻醉的镇痛效果。方法:选取本院2018年8月-2019年8月收治的160例稽留流产患者分为观察组与对照组各80例,两组均行无痛人工流产术,术前对照组使用枸橼酸芬太尼联合丙泊酚麻醉,观察组在对照组基础上使用氟比洛芬酯。对比两组术后6h、12h、24h、36h疼痛视觉模拟评分(VAS)差异,对比两组围术期平均动脉血压(MAP)、心率(HR)、收缩压(SBP)、舒张压(DBP)、手术时间、术后苏醒时间、丙泊酚用量各项指标,统计麻醉期间不良反应。结果:观察组术后不同时点VAS评分均低于对照组(P<0.05)。术前及术后MAP、HR、SBP、DBP水平两组及组内对比均无差异,手术时间对比无差异(均P>0.05);观察组术后苏醒时间(3.53±1.61min)、丙泊酚用量(2.21±1.27 mg/kg)少于对照组,用药后不良反应总发生率(5.0%)低于对照组(16.3%)(P<0.05)。结论:稽留流产无痛流产术中辅助使用氟比洛芬酯麻醉能获得更好的镇痛效果,并减少丙泊酚用量、缩短术后苏醒时间、降低药物不良反应发生。

Objective:To study the analgesic effect of flurbiprofen axetil combined with fentanyl citrate in missed abortion.Methods:160 women with missed abortion were selected and were divided into observation group and control group by random number table method from August 2018 to August 2019(80 cases in each group).All included women in the two groups were treated with painless abortion.The women in the control group were anesthetized by fentanyl citrate combined with propofol before operation,and the women in the observation group were treated by flurbiprofen except to fentanyl citrate combined with propofol.After abortion,the visual analogue scale(VAS)of women 6,12,24 and 36 hours after operation,the perioperative mean arterial blood pressure(MAP),heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP),operation time,recovery time,and propofol dosage of women were compared between the two groups.The incidence of adverse reactions during anesthesia of women in both groups was counted.Results:The VAS score of women in the observation group at different time points after abortion was significant lower than that of the women in the control group(P<0.05).There were no different in the values of MAP,HR,SBP,and DBP of all women before and after abortion,and there were also no different in the values of MAP,HR,SBP,and DBP of women between the two groups(P>0.05).The postoperative wake time and the dosage of propofol of women in the observation group were 3.53±1.61min and 2.21±1.27 mg/kg respectively,which were significant less than those of women in the control group,but the overall incidence of adverse reactions of women in the observation group was 5.0%,which was significant lower than that(16.3%)of women in the control group(P<0.05).Conclusion:Flurbiprofen axetil combined with fentanyl citrate used in missed abortion can achieve better analgesic effect,which can reduce the dosage using of propofol,shorten the recovery time after operation,and reduce the incidence of adverse drug reactions.