丁苯酞联合丹红注射液治疗急性脑梗死的疗效及其对PKC、CRP、PTX3的影响

Effect of butylphthalide combined with Danhong injection in the treatment of acute cerebral infarction and its influence on PKC,CRP and PTX3

目的探讨丁苯酞联合丹红注射液治疗急性脑梗死的疗效及对蛋白激酶C(PKC)、C反应蛋白(CRP)和正五聚体蛋白3(PTX3)的影响。方法选取2017年1月至2018年12月该院收治的100例急性脑梗死患者进行研究,采用随机数字表达法将所有急性脑梗死患者分为对照组和观察组,每组各50例。对照组给予丹红注射液治疗,观察组给予丁苯酞联合丹红注射液治疗。比较2组患者的疗效,治疗前后2组患者PKC、CRP、PTX3水平,欧洲卒中量表评分(ESS评分),日常生活能力评定量表(Barthel指数)及药物不良反应的发生情况。结果观察组总有效率明显高于对照组(82.00%vs.58.00%),差异有统计学意义(P<0.05)。治疗前,2组患者的PKC、CRP、PTX3水平、ESS评分及Barthel指数相比,差异无统计学意义(P>0.05);治疗后,2组患者PKC、CRP、PTX3水平均降低,且观察组PKC、CRP、PTX3水平降低幅度比对照组大,2组ESS评分及Barthel指数均改善,观察组优于对照组,差异均有统计学意义(P<0.05)。2组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论丁苯酞联合丹红注射液治疗急性脑梗死疗效确切,且可降低患者的PKC、CRP、PTX3水平,患者恢复好,日常生活能力提升,同时不增加不良反应发生率。

Objective To investigate the efficacy of butylphthalide combined with danhong injection in the treatment of acute cerebral infarction and its effects on protein kinase C(PKC),C reactive protein(CRP)and pentameter protein 3(PTX3).Methods From January 2017 to December 2018,100 patients with acute cerebral infarction admitted to the hospital were selected for study.All patients with acute cerebral infarction were divided into control group and observation group with random number expression method,50 in each group.The control group received Danhong injection,while the observation group received butylphthalide combined with Danhong injection.The efficacy,PKC,CRP,PTX3 levels,European stroke scale score(ESS score)and Barthel score of daily living scale before and after treatment were compared between the two groups,as well as the occurrence of adverse drug reactions.Results The total effective rate of observation group was significantly higher than that of control group(82.00%vs.58.00%),the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in PKC,CRP,PTX3,ESS and Barthel scores between the two groups(P>0.05).After treatment,the levels of PKC,CRP and PTX3 in the two groups were all reduced compared with those before treatment,and the reduction of PKC,CRP and PTX3 in the observation group was greater than that in the control group,and the ESS score and Barthel score were improved in each group,and the observation group was better than the control group,and the difference was statistically significant significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Butylphthalide combined with Danhong injection is effective in the treatment of acute cerebral infarction,and can reduce the levels of PKC,CRP,PTX3,improve the ability of daily life of patients,without increasing the incidence of adverse reactions.