清营汤加减联合寿胎灌肠汤对特发性畸形精子症患者的临床疗效

Clinical effects of Modified Qingying Decoction combined with Shoutai Enema Decoction on patients with idiopathic teratospermia

目的研究清营汤加减联合寿胎灌肠汤对特发性畸形精子症患者的临床疗效。方法 120例患者随机分为对照组和观察组,每组60例,对照组给予左卡尼汀,观察组给予清营汤加减联合寿胎灌肠汤,疗程60 d。检测临床疗效、精子形态学、精子活力、血清免疫功能指标(CD^3+、CD^4+、CD^8+、CD^4+/CD^8+)、精浆免疫功能指标(Ig G、Ig M、Ig A)、VEGF、MMP-3、MMP-9、不良反应发生率变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,观察组精子形态学较对照组改善(P<0.05),精子活力、CD^3+、CD^4+、CD^4+/CD^8+、精浆免疫功能指标、MMP-3、MMP-9升高(P<0.05),CD^8+、VEGF、不良反应发生率降低(P<0.05)。结论清营汤加减联合寿胎灌肠汤可有效改善特发性畸形精子症患者临床症状,安全性较高。

AIM To study the clinical effects of Modified Qingying Decoction combined with Shoutai Enema Decoction on patients with idiopathic teratospermia.METHODS One hundred and twenty patients were randomly assigned into control group(60 cases)for 60-day administration of levocarnitine,and observation group(60 cases)for 60-day administration of Modified Qingying Decoction combined with Shoutai Enema Decoction.The changes in clinical efficacy,sperm morphology,sperm vitality,serum immune function indices(CD^3+,CD^4+,CD^8+,CD^4+/CD^8+),seminal plasma immune function indices(IgG,IgM,IgA),VEGF,MMP-3,MMP-9,and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the observation group displayed improved sperm morphology as compared with the control group(P<0.05),along with increased sperm vitality,CD^3+,CD^4+,CD^4+/CD^8+,seminal plasma immune function indices,MMP-3 and MMP-9(P<0.05),and decreased CD8+,VEGF and incidence of adverse reactions(P<0.05).CONCLUSION For the patients with idiopathic teratospermia,Modified Qingying Decoction combined with Shoutai Enema Decoction can effectively improve clinical symptoms with high safety.