季节性流感疫苗免疫效果主要影响因素的研究进展

Research on the main factors influencing influenza vaccine effectiveness

季节性流感疫苗的免疫效果在不同的流感季节存在很大变化。尽管WHO每年会对流感疫苗株进行评估和更新,但疫苗免疫效果有时仍不可避免的不理想。本文对有关影响季节性流感疫苗免疫效果的文献进行综述,旨在提高季节性流感疫苗的免疫效果,为季节性流感的预防接种提供科学依据。综述结果显示流行株与疫苗株的匹配程度,免疫前暴露(自然感染或疫苗接种)、年龄以及自身免疫功能状况都会影响季节性流感疫苗的免疫效果。

Effectiveness of seasonal influenza vaccines varies greatly during the different flu seasons.Although the WHO assesses and updates influenza vaccine strains every year,the effectiveness of vaccine is sometimes not good.This review explores the various factors that influencing influenza vaccine effects in order to improve the effectiveness of influenza vaccines and provide a scientific basis for influenza vaccination.The results reveal that the degree of matching between epidemic strains and vaccine strains,pre-exposure(natural infection,vaccination),age,and immune status could all affect the vaccine effectiveness.