高甘油三酯血症性急性胰腺炎的研究进展

Research advances of hypertriglyceridemia acute pancreatitis

近年来随着生活方式的改变,高甘油三酯血症已成为我国急性胰腺炎发病的第二大原因。研究发现,高甘油三酯对急性胰腺炎的发病(包括复发)、疾病急性期严重程度以及后期胰腺修复均具有明确的影响。然而,当前高甘油三酯血症导致急性胰腺炎的发病机制尚不明确,研究多集中于游离脂肪酸、胰腺微循环障碍、钙超载、氧化应激、基因多态性等方面。在临床诊疗方面,也缺乏针对性的有效治疗手段,有待进一步研究。

In recent years,with the change of lifestyle in China,hypertriglyceridemia(HTG)has been the second leading cause of acute pancreatitis(AP).Recent studies have shown that HTG has long-lasting influences on AP onset(including recurrence),AP severity,as well as pancreatic regeneration.However,the underlying mechanisms of HTG-AP is still unclear,mainly focusing on free fatty acid,microcirculation disturbance,calcium overload,oxidative stress,gene polymorphism and so on.However,there is lack of effective intervention for the diagnosis and treatment of HTG-AP,which needs further study.