肠易激综合征患者焦虑情绪及糖代谢水平的关系研究

Relationship of anxiety and glucose metabolism in irritable bowel syndrome patients

目的研究肠易激综合征(irritable bowel syndrome,IBS)患者症状分型与焦虑情绪及糖代谢水平的关系。方法选取IBS患者确定症状分型,根据患者分为IBS-C组(31例)、IBS-D组(144例)、IBS-M组(15例),采用焦虑自评量表(SAS)评价各症状分型与患者焦虑情绪之间的关系;次日晨收集患者空腹血清检测糖代谢水平指标,二分类回归分析评价IBS患者焦虑情绪与糖代谢水平之间的关系。结果IBS-C、IBS-D、IBS-M三种分型非焦虑情绪占比分别为64.52%、78.47%、53.33%,3组间差异有统计学意义(P<0.05)。是否有焦虑情绪IBS患者之间的空腹血糖、HbA1c、2 h后血糖差异具有统计学意义(P<0.05),二分类回归结果显示HbA1c、2 h后血糖水平是IBS患者焦虑情绪的显著影响因素。结论IBS患者焦虑情绪与症状分型有关,IBS患者焦虑情绪受HbA1c、2 h后血糖水平影响。

Objective To study the relationship of symptom classification,anxiety and glucose metabolism in patients with irritable bowel syndrome(IBS).Methods According to symptom classification,IBS patients were divided into IBS-C group(n=31),IBS-D group(n=144),and IBS-M group(n=15).Self-rating anxiety scale(SAS)was used to evaluate the relationship of symptom classification and the anxiety of patients.Binary logistic regression analysis was used to evaluate the relationship of anxiety and glucose metabolism in IBS patients.Results The proportions of patients without anxiety with IBS-C,IBS-D and IBS-M were 64.52%,78.47%and 53.33%.The differences were statistically significant(P<0.05).The differences of fasting blood glucose,HbA1c and 2h blood glucose between IBS patients with anxiety or not were statistically significant(P<0.05).Binary logistic regression analysis showed that HbA1c and 2h blood glucose were the significant influencing factor of anxiety in IBS patients.Conclusions The anxiety of IBS patients is related to symptom classification.The anxiety of IBS patients is affected by HbA1c and 2h blood glucose.