支气管肺泡灌洗液诊断新型冠状病毒肺炎二例

Bronchoalveolar lavage fluid was used to diagnose two cases of 2019-nCoV infection

本文报道我院收治并行支气管肺泡灌洗诊断新型冠状病毒肺炎2例,1例有流行病学史、临床症状及影像学高度疑似,但反复咽拭子阴性患者;1例确诊新型冠状病毒肺炎患者,出院前临床症状消失,胸部CT显示影像学表现明显好转,咽拭子2次阴性,达到出院标准。我们对2例患者的支气管肺泡灌洗液,分别进行新冠病毒ORF 1ab基因、N基因及新冠病毒核酸检测。结果表明,支气管肺泡灌洗液新型冠状病毒核酸检测阳性率高,对疑诊或者确诊新型冠状病毒肺炎患者出院咽拭子核酸检测阴性但肺部仍残留病灶行支气管肺泡灌洗有助于尽早诊断及指导治疗、判断预后。

The case reports 2 cases of novel coronavirus pneumonia diagnosed by concurrent bronchoalveolar lavage in our hospital,1 case had a history of epidemiology,clinical symptoms and high imaging suspicion,but repeated negative throat swabs.One patient was diagnosed 2019-nCoV.Before the patient was discharged,the clinical symptoms disappeared,the chest CT showed significant improvement,and the pharynx swab was twice negative,reaching the discharge standard.We detected the ORF 1ab gene,the N gene and the nucleic acid of the new coronavirus in the broncho-alveolar lavage fluid of 2 patients.The results showed that the positive rate of bronchoalveolar lavage for detection of new coronavirus nucleic acid was high,and bronchoalveolar lavage for suspected or confirmed new coronavirus pneumonia patients with negative detection of nucleic acid in pharynx swabs but still residual lung lesions was helpful for early diagnosis,treatment and prognosis.