阿尔茨海默病患者血清补体C5a水平及其与炎症因子的相关性

Serum complement C5a levels and its association with inflammatory factors in patients with Alzheimer’s disease

目的探讨阿尔茨海默病(Alzheimer’s disease,AD)患者血清补体C5a水平及其与炎症因子的相关性,阐明其临床意义。方法选择杭州市第七人民医院2018年1月-2018年12月的AD患者110例作为AD组,同期健康体检者110例作为对照组。测定血清C5a水平及血清高敏C-反应蛋白(high sensitive C-reaction protein,hs-CRP)、白细胞介素1β(interleukin-1β,IL-1β)、IL-6、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平。结果AD组简易精神状态量表(simple mental state scale,MMSE)评分[(15.62±3.21)分]低于对照组[(29.34±3.82)分],t=28.839,P<0.05,C5a水平[(73.51±9.42)pg/mL]高于对照组[(64.29±9.34)pg/mL],t=7.290,P<0.05。AD组血清hs-CRP、IL-1β、IL-6、TNF-α水平[(5.03±0.60)pg/mL、(37.49±7.46)pg/mL、(105.34±13.13)pg/mL、(196.54±12.06)pg/mL]高于对照组(t=45.395、9.939、25.704、7.086,均P<0.05)。AD患者血清C5a、hs-CRP、IL-1β、IL-6、TNF-α水平与MMSE评分均呈负相关(r=-0.421、-0.523、-0.436、-0.445、-0.507,均P<0.05)。AD患者血清C5a与血清hs-CRP、IL-1β、IL-6、TNF-α水平均呈正相关(r=0.564、0.602、0.641、0.539,均P<0.05)。结论AD患者血清补体C5a水平升高,C5a水平与AD患者认知功能和血清炎症因子水平关系密切。

Objective To investigate the serum complement C5 a level and its relationship with inflammatory factors in patients with Alzheimer’s disease(AD)in order to elucidate its clinical significance.Methods Total 110 patients with AD in Hangzhou Seventh People’s Hospital from January to December 2018 were selected as AD group,and 110 healthy subjects were selected as control group.The serum C5 a level,high sensitive C-reaction protein(hs-CRP),interleukin-1β(IL-1β),IL-6 and tumor necrosis factor-α(TNF-α)levels were measured.Results The score of the simple mental state scale(MMSE)of the AD group[(15.62±3.21)scores]was lower than that of the control group[(29.34±3.82)scores,t=28.839,P<0.05],and the level of C5 a[(73.51±9.42)pg/mL]was higher than that of the control group[(64.29±9.34)pg/mL,t=7.290,P<0.05].The levels of serum hs-CRP,IL-1β,IL-6 and TNF-αin the AD group[(5.03±0.60)pg/mL,(37.49±7.46)pg/mL,(105.34±13.13)pg/mL,(196.54±12.06)pg/mL]were higher than those in the control group(t=45.395,9.939,25.704,7.086,all P<0.05).The levels of serum C5 a,hs-CRP,IL-1β,IL-6 and TNF-αin AD patients were negatively correlated with MMSE scores(r=-0.421,-0.523,-0.436,-0.445,-0.507,all P<0.05).The serum C5 a was positively correlated with serum hs-CRP,IL-1β,IL-6 and TNF-αlevels in AD patients(r=0.564,0.602,0.641,0.539,all P<0.05).Conclusion Serum complement C5 a level is elevated in patients with AD,and it is closely related to cognitive function and serum inflammatory factor levels in AD patients.