曲美他嗪联合比索洛尔对缺血性心肌病患者NT-proBNP水平及心功能的影响

Effect of trimetazidine combined with bisoprolol on NT-proBNP level and cardiac function in patients with ischemic cardiomyopathy

目的探讨曲美他嗪联合比索洛尔治疗缺血性心肌病患者的临床效果以及对患者氨基末端脑钠肽前体(N terminal pro B type natriuretic peptide,NT-proBNP)和心功能等指标产生的影响作用。方法将海口市第三人民医院自2016年1月-2018年10月间收治的缺血性心肌病患者86例作为研究对象,随机数字表法分为比索洛尔治疗的对照组和曲美他嗪联合比索洛尔治疗的研究组各43例,分别治疗3个月后观察2组患者心功能各项指标和NT-proBNP水平变化情况。结果研究组患者临床总有效率为90.70%,明显高于对照组的74.42%(P<0.05);治疗后2组患者LVEDd和LVESd水平均明显降低,LVEF水平明显升高,其中研究组各项指标改善情况均显著优于对照组,组间差异具有统计学意义(均P<0.05);治疗后2组患者NT-proBNP水平均明显降低,其中研究组降低程度明显优于对照组,组间差异具有统计学意义(P<0.05)。结论曲美他嗪联合比索洛尔治疗缺血性心肌病能够明显改善患者心功能各项指标,降低NT-proBNP水平,提高临床治疗的总有效率,值得推广使用。

Objective To investigate the clinical effect of trimetazidine combined with bisoprolol on the treatment of ischemic cardiomyopathy and its effect on N terminal pro B type natriuretic peptide(NT-proBNP)and cardiac function.Methods Total 86 patients with ischemic cardiomyopathy admitted to Haikou Third People’s Hospital from January 2016 to October 2018 were randomly divided into two groups:control group treated with bisoprolol and study group treated with trimetazidine and bisoprolol,43 cases in each group.After 3 months of treatment,the changes of heart function indexes and NT proBNP level were observed.Results The total clinical effective rate of the study group was 90.70%,which was significantly higher than that of the control group(74.42%,P<0.05).After treatment,the levels of LVEDd and LVESd in the two groups were significantly decreased,and the levels of LVEF were significantly increased.The improvement of the indexes in the study group was significantly better than those in the control group(all P<0.05).After treatment,the levels of NT-proBNP in both groups were significantly decreased,and the degree of reduction in the study group was significantly better than that in the control group(P<0.05).Conclusion Trimetazidine combined with bisoprolol can significantly improve the cardiac function of patients with ischemic cardiomyopathy,reduce NT-proBNP level,and improve the total efficiency of clinical treatment.It is worth popularizing.