组织工程用纤维增强天然多糖水凝胶的进展

Progress in Fiber-reinforced Natural Polysaccharide Hydrogel for Tissue Engineering Application

天然多糖水凝胶具有良好的生物相容性,然而其力学性能调节幅度小,无法满足组织工程应用巨大的需求。通过纤维增强法,不仅可显著提高天然多糖水凝胶的力学性能,还能调节复合水凝胶的降解性能、促进细胞粘附、增殖与分化行为及其组织沉积。常用的天然多糖组织工程水凝胶的纤维增强方法有物理共混法、化学作用法、静电驱动法与自组装法等。本文综述了纤维增强水凝胶的结构与功能特点,讨论了纤维增强对组织工程水凝胶的意义,以期对纤维增强组织工程水凝胶的发展起到促进作用。

Natural polysaccharide hydrogels with good biocompatibility are widely used in the field of tissue engineering.However,the poor mechanical properties of tissue polysaccharide hydrogels limit the application of tissue engineering.The method of fiber reinforcement not only can significantly improve their mechanical properties,but also adjust the degradation properties of composite hydrogels,promote cellular adhesion and proliferation including differentiation and tissue deposition.The fiber reinforcement methods can be classified into physical blending,chemical bonding,electrostatic driving and self-assembly.We review the structural and functional characteristics of various fiber-reinforced hydrogels,and expound the significance of fiber-reinforced methods for tissue engineering.