suPAR在肾小球疾病中的意义

Significance of suPAR in glomerular diseases

可溶性尿激酶型纤溶酶原激活物受体(soluble urokinase-type plasminogen activator receptor,suPAR)是一种新型的生物标志物,可用于多种疾病的诊断、评估和预后。大量的研究证明,suPAR与炎症感染性疾病、心血管疾病、自身免疫系统疾病、肿瘤及慢性肝脏疾病等密切相关,近年来随着对suPAR的不断发现,为该领域提供了新的视野,suPAR与肾小球疾病的发生、发展亦有着密切的联系,如局灶节段性肾小球硬化、膜性肾病、微小病变型肾病、lgA肾病、糖尿病肾病、狼疮性肾炎等,本文就suPAR在肾小球疾病中的意义进行综述。

The soluble urokinase-type plasminogen activator receptor(suPAR)is a new type of biomarkers,and can be used for a variety of diagnosis,evaluation and prognosis of many diseases.Numerous studies have proved that suPAR is closely related to inflammatory diseases,cardiovascular diseases,autoimmune diseases,tumors and chronic liver diseases.In recent years,important insights have been gained into the pathogenic role of suPAR in glomerular diseases,including focal segmental glomerular sclerosis,membranous nephropathy,minimal change disease,lgA nephropathy,diabetic nephropathy,and lupus nephritis etc.Here,we review the role of suPAR in glomerular diseases.