C1q肿瘤坏死因子相关蛋白3的临床研究新进展

New progress in clinical research of C1q tumor necrosis factor-related protein 3

C1q肿瘤坏死因子(TNF)相关蛋白(CTRPs)是继瘦素、脂联素后一种新发现的分泌于脂肪组织的蛋白超家族,到目前为止这个超家族已被证实具有强大的生物学功能,在多种组织类型中发现了对代谢、炎症的广泛影响。其中研究最多的因子C1q肿瘤坏死因子相关蛋白3(CTRP3)在代谢性疾病、心血管疾病、肾脏疾病及炎症等方面的重要作用也逐渐被发掘。本文就CTRP3的发现、生物学作用及现有临床研究做一综述。

After leptin and adiponectin,C1q tumor necrosis factor(TNF)-related proteins(CTRPs)are a newly discovered protein superfamily secreted in adipose tissue,which has been proven to be powerful biological functions so far.There are many broad effects on metabolism and inflammation,which were found in multiple organizational types.Among them,the factor studied most-frequently,C1q tumor necrosis factor-related protein 3(CTRP3),has been gradually explored for the important role in metabolic diseases,cardiovascular diseases,kidney diseases and inflammation.This review will focus on discovery,biological function and current clinical research of CTRP3.