摘要
目的探讨支气管哮喘患儿血清谷胱甘肽过氧化物酶(GSH-Px)及核因子E2相关因子2(Nrf2)水平与其严重程度的关系。方法选取2016年2月-2019年2月我院收治的131例支气管哮喘患儿作为研究对象。选取同期120例健康体检儿童作为对照组。检测二组血清GSH-Px、Nrf2水平并分析二者与支气管哮喘患儿严重程度的关系。结果支气管哮喘组血清GSH-Px及Nrf2水平均低于对照组,差异均有统计学意义(均P<0.05)。重度组患儿血清GSH-Px及Nrf2水平明显低于轻、中度组,差异均有统计学意义(均P<0.05)。Logistic回归分析显示年龄、病程、25-二羟基维生素D3[1,25-(OH)2D3]、基质金属蛋白酶9(MMP9)、血清免疫球蛋白E(IgE)、用药、规律用药、GSH-Px、Nrf2与支气管哮喘严重程度密切相关。结论支气管哮喘患儿血清GSH-Px、Nrf2水平与其严重程度存在联系,且二者均为支气管哮喘患儿的独立保护因素。
Objective To investigate the relationship between serum glutathione peroxidase(GSH-Px) and nuclear factor erythroid 2-related factor 2(Nrf2) levels and the severity in children with bronchial asthma.Methods From February 2016 to February 2019,a total of one hundred and thirty-one children with bronch-ial asthma treated in The Sixth People′s Hospital of Chengdu were selected as the study subjects.120 healthy children in the same period were selected as control group.The levels of GSH-Px and Nrf2 in serum of the two groups were detected and the relationship between them and the condition of children with bronchial asthma was analyzed.Results The levels of serum GSH-Px and Nrf2 in bronchial asthma group were lower than those in control group,the difference was statistically significant(P<0.05).The serum levels of GSH-Px and Nrf2 in severe group were lower than those in mild and moderate group,the difference was statistically significant(P<0.05).Logistic regression analysis showed that age,course of disease,1,25-(OH)2 D3,MMP9,IgE,medication,regular medication,GSH-Px,Nrf2 were closely related to the severity of bronchial asthma.Conclusion The serum levels of GSH-Px and Nrf2 in children with bronchial asthma are correlated with the severity of asthma.Both of them are independent protective factors for children with bronchial asthma.
作者
范慧海
彭丰
何静
Fan Huihai;Peng Feng;He Jing(The Si.rth People's Hospital of Chengdu,Chengdu 610051,China)
出处
《中国煤炭工业医学杂志》
2020年第2期159-163,共5页
Chinese Journal of Coal Industry Medicine
基金
四川省卫生厅科研基金(编号:20120331)。