2014-2018年仁寿县疑似预防接种异常反应监测结果分析

Monitoring Results of Suspected Adverse Events Following Immunization in Renshou County From 2014 to 2018

目的对仁寿县疑似预防接种异常反应(adverse events following immunization,AEFI)监测结果进行分析,了解全县疑似预防接种异常反应的发生特征,对疫苗的安全性和预防接种服务质量进行评价。方法通过中国免疫规划信息管理系统收集2014-2018年仁寿县发生的AEFI个案数据,采用描述性流行病学方法对监测数据进行分析。结果2014-2018年仁寿县AEFI发现后48 h内报告率为99.42%,48 h内调查率、调查后7 d内完成初步调查报告率、调查后3 d内报告率、个案调查表关键项目完整率、AEFI分类率、报告单位覆盖率均为100%。涉及AEFI报告的一类和二类疫苗有23种,报告AEFI病例343例,报告发生率为19.82/10万,其中一般反应326例(95.04%),报告发生率为18.83/10万,异常反应17例(4.96%),报告发生率为0.98/10万,无疫苗质量事故、接种事故、偶合症和心因性反应。1岁及以下婴幼儿253例(4.96%),男女性别比为1.29∶1,4-9月274例(79.88%),一类疫苗的无细胞百白破和白破(儿童型)分别占162例(47.20%)和27例(7.87%)。结论2014-2018年,仁寿县AEFI监测系统运行良好,各项监测指标均达到《全国疑似预防接种异常反应监测方案》(下称《监测方案》)要求。根据WHO提供的数据,仁寿县的AEFI报告发生率在正常、合理的范围内,所有的AEFI病例转归及预后均较好,表明仁寿县使用的疫苗安全性好,预防接种服务质量有保障。

Objective To analyze the results of Renshou County suspected adverse events following immunization(AEFI)monitoring system and understand the occurrence characteristics of suspected AEFI,in order to evaluate the safety of vaccine and the quality of vaccination service.Methods Data of AEFI cases reported in Renshou County from 2014 to 2018 were collected from China Immunization Planning Information Management System and were analyzed by descriptive epidemiological method.Results From 2014 to 2018,99.42%of cases were reported within 48 hours after AEFI was detected in Renshou County.The survey rate within 48 hours,the basic report completion rate within 7 days,the reporting rate within 3 days,the completion rate of key items in the case questionnaire,the classification rate of AEFI,and the coverage rate of reporting units were all 100%.There were 23 types of class Ⅰ and class Ⅱ vaccines involved in AEFI report,343 AEFI cases were reported with a incidence of 19.82/100000,of which 326 cases(95.04%)were general reactions,the incidence was 18.83/100000 and 17 cases(4.96%)were abnormal reactions,the incidence rate was 0.98/100000,and there were no vaccine quality accidents,vaccination accidents,coincidental symptoms and psychogenic reactions.There were 253 cases(4.96%)of infants and children aged 1 year and below.The sex ratio of man to women was 1.29∶1.From April to September,274 cases(79.88%)were reported,among them,AEFI in class Ⅰ vaccines of Acellular DPT and DPT(childhood type)were 162 cases(47.20%)and 27 cases(7.87%),respectively.Conclusion From 2014 to 2018,the AEFI monitoring system in Renshou County is running well,all monitoring indicators have met the requirements of the national monitoring program for suspected AEFI.According to WHO data,the incidence of AEFI reported in Renshou County is in the normal and reasonable range,all the AEFI cases have good outcomes and prognosis,indicating that the vaccines used in Renshou County are rather safe and the quality of vaccination services is guaranteed.