宫腔镜联合腹腔镜探查术对不孕不育患者受孕情况及血清E2、FSH水平影响

Effect of Hysteroscopy and Laparoscopy on Fertility and Serum E2 and FSH Levels in Infertile Patients

目的探究宫腔镜联合腹腔镜探查术对不孕不育患者受孕情况及血清雌二醇(E2)、卵泡刺激素(FSH)水平的影响。方法回顾性分析苏州东吴中西医结合医院2017年5月至2018年12月收治的女性不孕不育患者108例,按不同治疗方法分为对照组(输卵管碘油造影术治疗)与观察组(宫腔镜联合腹腔镜探查术治疗),各54例。对比2组术后3个月临床疗效及受孕情况,比较2组术前及术后3个月雌二醇、FSH水平。结果术后3个月,观察组临床疗效(87.04%)显著高于对照组(70.37%)(P<0.05)。术后3个月观察组输卵管通畅率(90.74%)及正常受孕率(83.33%)均显著高于对照组(72.22%、66.67%),自然流产率(1.85%)显著低于对照组(16.67%)(P<0.05)。与术前比,术后3个月2组血清E2水平均上升,且观察组显著高于对照组(P<0.05);2组血清FSH水平均降低,且观察组显著低于对照组(P<0.05)。结论宫腔镜与腹腔镜联合探查术可有效调节不孕不育患者血清E2及FSH水平,改善受孕情况,疗效显著。

Objective To investigate the effect of hysteroscopy and laparoscopy on fertility and serum E2 and FSH levels in infertile patients.Methods Totally 108 cases of female infertility patients admitted to suzhou dongwu hospital of integrated traditional and western medicine from May 2017 to December 2018 were retrospectively selected.According to different treatment methods,they were divided into control group(oviduct iodide radiography)and observation group(hysteroscopy combined with laparoscopy),with 54 cases each.The clinical efficacy and pregnancy status of the two groups were compared 3 months after the operation,and the levels of estradiol and FSH were compared before and 3 months after the operation.Results At 3 months after surgery,the clinical effect of the observation group(87.04%)was significantly higher than that of the control group(70.37%)(P<0.05).The tubal patency rate(90.74%)and normal conception rate(83.33%)of the observation group at 3 months after operation were significantly higher than those of the control group(72.22%,66.67%),and the natural abortion rate(1.85%)was significantly lower than that of the control group(16.67%)(P<0.05).Compared with before surgery,the serum E2 level of the two groups increased 3 months after the operation,and the observation group was significantly higher than the control group(P<0.05);the serum FSH level of the two groups decreased,and the observation group was significantly lower than the control group(P<0.05).Conclusion Combined hysteroscopy and laparoscopy can effectively regulate serum E2 and FSH levels in infertile patients,improve fertility,and have significant effects.