无抽搐电休克治疗难治性精神分裂症的临床效果探讨

Clinical Effect of Non-Convulsive Electroconvulsive Therapy for Refractory Schizophrenia

目的探讨无抽搐电休克治疗难治性精神分裂症的临床疗效。方法选取云南省昆明市精神病院2018年1月至2019年1月接诊的难治性精神分裂症患者66例作为此次研究对象,采用随机数字表法分为对照组和研究组,各33例。对照组行口服奥氮平药物治疗;研究组在口服奥氮平治疗基础上行无抽搐电休克治疗。比较2组难治性精神分裂症患者接受各自治疗方案之后的临床效果。结果研究组治疗之后阳性与阴性症状量表(PANSS)总分为(57.06±6.29)分,阳性症状评分为(13.22±3.69)分,一般病理评分为(23.72±5.53)分,阴性症状评分为(18.12±4.78)分;对照组治疗之后PANSS总分为(69.11±9.29)分,阳性症状评分为(19.52±4.85)分,一般病理评分为(27.11±8.25)分,阴性症状评分为(20.33±5.37)分。2组治疗之后的PANSS总分、阳性症状评分、阴性症状评分以及一般病理评分比较差异有统计学意义(P<0.05);研究组治疗之后韦氏记忆量表WMS再认评分为(9.11±2.13)分,联想得分为(10.11±4.65)分;对照组治疗之后WMS再认评分为(7.12±2.85)分,联想得分为(7.68±2.55)分。2组治疗之后的WMS再认以及联想得分比较差异有统计学意义(P<0.05)。结论临床中针对难治性精神分裂症患者,为其提供无抽搐电休克治疗效果理想,能够显著改善患者的临床表现症状,提高患者记忆功能标。

Objective To investigate the clinical effect of non-convulsive electroconvulsive therapy in patients with refractory schizophrenia.Methods From January 2018 to January 2019,a total of 66 patients with treatment-resistant schizophrenia admitted to Kunming Psychiatric Hospital in Yunnan Province were selected as the subjects of this study.The control group was treated with oral olanzapine.The study group received antic electroconvulsive therapy on the basis of oral olanzapine.The clinical effect of two groups of refractory schizophrenia patients after receiving their respective treatment regimens were compared.Results After treatment,the total score of PANSS in the study group was(57.06±6.29)points,the positive symptom score was(13.22±3.69)points,the general pathological score was(23.72±5.53)points,and the negative symptom score was(18.12±4.78)points.After treatment,the total score of PANSS in the control group was(69.11±9.29)points,the positive symptom score was(19.52±4.85)points,the general pathological score was(27.11±8.25)points,and the negative symptom score was(20.33±5.37)points.After treatment,the total PANSS score,positive symptom score,negative symptom score and general pathological score of the two groups were significantly different(P<0.05).After treatment,the WMS recognition score of the study group was(9.11±2.13)points,and the association score was(10.11±4.65)points.After treatment,the WMS recognition score of the control group was(7.12±2.85)points,and the association score was(7.68±2.55)points.Conclusion Non-convulsive electroconvulsive therapy is effective for refractory schizophrenia patients,which can significantly improve their clinical manifestations and symptoms,and improve their memory function.