草酸艾司西酞普兰片联合小剂量奥氮平治疗抑郁症患者的疗效与安全性观察

Therapeutic Effect and Safety of Escitalopram Oxalate Tablet Combined with Low-dose Olanzapine on Patients with Depression

目的探讨草酸艾司西酞普兰片联合小剂量奥氮平治疗抑郁症患者的疗效与安全性。方法选取2017年2月至2019年2月徐州市东方人民医院收治的抑郁症患者80例,采用数表法分为2组,每组40例。单药组患者给予单独草酸艾司西酞普兰治疗,联合用药组患者在以上基础上加用小剂量奥氮平治疗,治疗周期为8周。比较2组患者治疗前后汉密尔顿抑郁量表(HAMD)评分、总体治疗效果及其不良反应。结果联合用药组患者治疗后4、8、12周HAMD评分均显著低于单药组(P<0.05);总有效率显著高于单药组(97.5%vs.80.00%,P<0.05);检测血清神经元特异性烯醇化酶(NSE)、S100B蛋白(S-100B)、白介素-6(IL-6)水平均显著低于单药组(P<0.05)。2组患者不良反应发生率比较,差异无统计学意义(12.5%vs.17.5%,P>0.05)。结论与草酸艾司西酞普兰片单独治疗比较,加用小剂量奥氮平治疗可显著降低抑郁症患者抑郁水平,提升总体治疗效果,安全性较高。

Objective To investigate the effect and safety of escitalopram oxalate tablet combined with lowdose olanzapine in the treatment of patients with depression.Methods Totally 80 patients with depression who were admitted to Xuzhou Oriental People's Hospital from February 2017 to February 2019 were randomly divided into two groups,40 cases per group.Patients in the single drug group were treated with escitalopram oxalate tablet alone,and patients in the combination group were treated with low-dose olanzapine on the basis of single drug group.The treatment period was 8 weeks.The Hamilton's Depression Scale scores,overall therapeutic effect and adverse reactions were compared between the two groups.Results The 4-,8-and 12-week HAMD scores in the combination group were significantly lower than those in the single drug group(P<0.05);the total effective rate was significantly higher than the single drug group(97.5%vs.80.00%,P<0.05).After treatment,the levels of NSE,S-100B,and IL-6 in the combined drug group were significantly lower than those in the single drug group(P<0.05).There was no significant difference in the adverse reaction rate between the two groups(P>0.05).Conclusion Compared with escitalopram oxalate tablet alone,the combination of escitalopram oxalate tablet and low-dose olanzapine was effective and safe in the treatment of depression patients.