赖氨葡锌颗粒辅助治疗小儿急性腹泻病及对CK-MB、AST的影响

Adjuvant Treatment of Lysine and Zinc Particles in Children with Acute Diarrhea and its Effect on CK-MB and AST

目的探讨赖氨葡锌颗粒辅助治疗小儿急性腹泻病及对肌酸激酶同工酶(CK-MB)、天冬氨基氨酸转移酶(AST)的影响。方法选取遵义市妇幼保健院2018年8月至2019年8月接诊的小儿急性腹泻病患者88例作为本次研究对象,按照随机数字表法分为对照组和研究组,各44例。对照组使用常规综合疗法,研究组则联合赖氨葡锌颗粒辅助治疗,2组均治疗14 d。比较2组临床疗效,症状改善情况以及治疗前后血清CK-MB、AST水平的变化。结果研究组的临床总有效率为97.73%,高于对照组的72.73%(P<0.05);与对照组相比,研究组的大便性状变稠、腹泻停止、腹痛停止、大便镜检正常时间均明显缩短(P<0.05);与治疗前相比,治疗后2组血清肌酸激酶同工酶(CK-MB)、天冬氨基氨酸转移酶(AST)水平均降低,且研究组低于对照组(P<0.05)。结论赖氨葡锌颗粒可有效缓解小儿急性腹泻病患者的临床症状,缩短症状改善时间,降低血清CK-MB、AST水平。

Objective To investigate the adjuvant treatment of lysine and zinc particles in children with acute diarrhea and its effect on CK-MB and AST.Methods A total of 88 cases of pediatric acute diarrhea patients admitted to zunyi maternal and child health hospital from August 2018 to August 2019 were selected as the subjects of this study.According to the random number table method,they were divided into the control group and the research group,with 44 cases in each.The control group was treated with conventional comprehensive therapy,while the research group was treated with lyme zinc granule for 14 days.Clinical efficacy,symptom improvement and serum ck-mb and AST levels before and after treatment were compared between the two groups.Results The total clinical effective rate of the study group was 97.73%,which was higher than 72.73%of the control group(P<0.05);compared with the control group,the stools of the study group were thickened,diarrhea stopped,abdominal pain stopped,and the normal time of fecal microscopy was significantly shortened(P<0.05);compared with before treatment,serum CK-MB and AST levels in the two groups were reduced after treatment,and the study group was lower than the control group(P<0.05).Conclusion The lysine gluconate and zinc granules can effectively alleviate the clinical symptoms of children with acute diarrhea,shorten the time to improve symptoms,and reduce serum CK-MB and AST levels.