盐酸溴己新联合阿奇霉素对支原体肺炎患儿肺功能及TNF-α、IL-6的影响

Effects of Bromhexine Hydrochloride Combined with Azithromycin on Lung Function and TNF-αand IL-6 in Children with Mycoplasma Pneumonia

目的研究盐酸溴己新联合阿奇霉素对支原体肺炎患儿肺功能及血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)的影响。方法选取2018年3月至2019年3月内蒙古兴安盟人民医院收治的100例支原体肺炎患儿,按照治疗方法的不同分为对照组和研究组,各50例。对照组行阿奇霉素治疗,研究组联合盐酸溴己新治疗,2组均治疗7 d。比较2组临床总有效率,血清炎性因子水平的变化以及肺功能指标。结果研究组的总有效率为96.00%,高于对照组的82.00%(P<0.05);与治疗前相比,治疗后2组血清IL-6、IL-13、TNF-α水平均降低,且研究组低于对照组(P<0.05);与治疗前相比,治疗后2组FVC、FEV1及研究组FEV1/FVC均升高,且研究组高于对照组(P<0.05)。结论盐酸溴己新联合阿奇霉素可显著缓解支原体肺炎患儿的临床症状,改善肺功能,抑制炎性反应,且疗效显著优于单纯使用阿奇霉素治疗。

Objective To study the effects of bromhexine hydrochloride combined with azithromycin on lung function and TNF-α and IL-6 in children with mycoplasma pneumonia.Methods A total of 100 children with mycoplasma pneumonia admitted to xingan league people's hospital in Inner Mongolia from March 2018 to March 2019 were selected.According to different treatment methods,they were divided into control group and research group,with 50 cases each.The control group was treated with azithromycin,the research group was treated with bromohexine hydrochloride,and both groups were treated for 7 days.The clinical total response rate,serum inflammatory factor levels and lung function indexes were compared between the two groups.Results The total efficiency of the study group was 96.00%,which was higher than that of the control group 82.00%(P<0.05);serum levels of IL-6,IL-13 and TNF-α decreased in both groups after treatment compared with those before treatment,and the study group was lower than the control group(P<0.05);compared with before treatment,FVC,FEV1 in the two groups and FEV1/FVC in the study group increased after treatment,and the study group was higher than the control group(P<0.05).Conclusion Bromohexine hydrochloride combined with azithromycin can significantly relieve the clinical symptoms of mycoplasma pneumonia in children,improve lung function,inhibit inflammatory response,and the efficacy is significantly better than azithromycin alone.