1[1]Dunham I, Shimizu N, Roe BA, et al. The DNA sequence of human chromo -some 22 [ J ]. Nature, 1999,402 (6 761 ): 489 - 495.
2[2]Hattori M, Fujiyama A, Taylor TD, et al. The DNA sequence of human chromosome 21 [J ]. Nature, 2000, 405 (6 784): 311 - 319.
3[3]Deloukas P, Matthews LH, Ashurst J, et al. The DNA sequence and compar -ative analysis of human chromosome 20 [ J ]. Nature, 2001,414 ( 6 866 ):865 - 871.
4[4]Hillier LW, Fulton RS, Fulton LA, et al. The DNA sequence of human chromosome 7[J]. Nature, 2003, 424(6 945): 157 - 164.
5[5]Heilig R, Eckenberg R, Petit JL, et al. The DNA sequence and analysis of human chromosome 14 [ J]. Nature, 2003, 421 (6 923 ): 601 - 607.
6[6]Skaletsky H, Kuroda Kawaguchi T, Minx P J, et al. The male - specific region of the human Y chromosome is a mosaic of discrete sequence classes [J]. Nature, 2003, 423(6 942): 825 - 837.
7[7]Butcher SP. Target discovery and validation in the post - genomic era[J].Neurochem Res, 2003, 28(2): 367 - 371.
8[8]Thayer AM. Great expectations - biopharmaceutical. industry expects success from new drug therapies and a full product development pipeline [ J ].Chemical Engineering News, 1998, 76(32): 19.
9[9]O Reilly MS. Endostain: an endogenous inhibitor of angiogesis and tumor growth[J]. Cell, 1997, 88 (2): 277 -285.