降钙素原和IL-6对胎膜早破新生儿感染的诊断价值

Value of procalcitonin and IL-6 in the diagnosis of infections in neonates with premature rupture of maternal membranes

目的观察降钙素原(PCT)、白细胞介素-6(IL-6)在胎膜早破新生儿感染诊断中的价值。方法收集胎膜早破新生儿50例为研究对象,其中新生儿感染组27例,非感染组23例,比较两组新生儿的血清PCT和IL-6水平,并采用受试者工作特征曲线(ROC)和ROC曲线下面积(AUC)分析PCT和IL-6对胎膜早破新生儿感染的诊断效能。结果感染组新生儿的PCT和IL-6水平均明显高于非感染组(P<0.01)。PCT、IL-6诊断胎膜早破新生儿感染的灵敏度、特异度、AUC分别为66.93%、83.17%、0.801和74.16%、67.35%、0.724。结论新生儿PCT和IL-6检测对胎膜早破新生儿感染的诊断具有一定价值。

Objective To observe the clinical value of procalcitonin(PCT)and interleukin-6(IL-6)in the diagnosis of infections in neonates with premature rupture of maternal membranes.Methods Fifty neonates with premature rupture of maternal membranes were collected as study objects,including 27 cases in the Infected Group and 23 cases in the NonInfected Group.The serum PCT and IL-6 levels of the two groups were compared.The diagnostic efficacy of PCT and IL-6 in infections in neonates with premature rupture of maternal membranes was analyzed with ROC and the area under ROC curve(AUC).Results The PCT and IL-6 levels in the neonates in the Infected Group were significantly higher than those in the Non-Infected Group(P<0.01).The sensitivity,specificity and AUC of PCT and IL-6 were 66.93%,83.17%,0.801,74.16%,67.35%and 0.724,respectively.Conclusion The detection of PCT and IL-6 in neonates is of certain significance for the diagnosis of infection in neonates with premature rupture of membranes.