益气养阴活血方治疗代谢综合征临床分析及对其胰岛素抵抗的影响

The Clinical Analysis of Invigorate Qi and Nourishing Yin for Activating Blood Recipe in the Treatment of Metabolic Syndrome and Its Influence on the Insulin Resistance

目的探讨益气养阴活血方对代谢综合征患者疗效及对其胰岛素抵抗的影响。方法将200例代谢综合征患者随机分为2组,治疗组100例给予益气养阴活血方联合西药常规治疗,对照组100例仅予西药常规治疗,观察12周,治疗前后采集血液样本,检测空腹血糖(FBG)、餐后2 h血糖(2h PG)、糖化血红蛋白(Hb Alc)、胰岛素抵抗指数(HOMA-IR)、瘦素(LEP)、脂联素(APN)、血脂四项(TC、TG、HDL-C、LDL-C)等,并测量治疗前后血压(BP)、体重(BW)、腰围、体重指数(BMI),以评价临床疗效及胰岛素抵抗情况。结果2组FBG、2h PG、Hb Alc、TC、TG、HDL-C、LDL-C、BP、BW、BMI、腰围均较治疗前明显下降,治疗组下降的更明显(P<0.05)。2组HOMA-IR、LEP、APN均比治疗前改善,治疗组改善更明显。结论益气养阴活血方联合西药常规治疗比单纯西药治疗可更好地控制血糖,改善代谢综合征,改善胰岛素抵抗状态。

Objective To investigate the effect of invigorate qi and nourishing yin for activating blood recipe on metabolic syndrome and its effect on insulin resistance.Methods 200 patients with metabolic syndrome were randomly divided into 2 groups,the treatment group 100 cases was treated with invigorate qi and nourishing yin for activating blood recipe and conventional western medicine therapy,the control group 100 cases with only conventional western medicine treatment,after 12 weeks blood samples collected before and after the treatment,detection of fasting blood glucose(FBG),postprandial 2 hours blood glucose(2 HPG),glycosylated hemoglobin(HbAlc),insulin resistance index(HOMA IR),leptin(LEP),adiponectin(APN),blood lipid four(TC,TG,HDL-C,LDL-C).Blood pressure(BP),body weight(BW),waist circumference and body mass index(BMI)were measured before and after treatment to evaluate the clinical efficacy and insulin resistance.Results FBG,2 h PG,HbAlc,TC,TG,HDL-C,LDL-C,BP,BW,BMI and waist circumference of the two groups all decreased significantly compared with that before treatment,and the decrease was more obvious in the treatment group(P<0.05).The improvement of HOMA-IR,LEP and APN in the two groups was more obvious than that before treatment.Conclusion Invigorate qi and nourishing yin for activating blood recipe combined with western medicine conventional treatment can better control blood glucose,improve metabolic syndrome and improve insulin resistance than the western medicine treatment alone.