血清甲胎蛋白及β-人绒毛膜促性腺激素检测在早期先兆流产预测中的应用分析

Application analysis of serum alpha-fetoprotein and human chorionic gonadotropin-β detection in prediction of early threatened abortion

目的探讨血清甲胎蛋白(AFP)及β-人绒毛膜促性腺激素(β-HCG)检测在早期先兆流产预测中的应用。方法选择菏泽市妇幼保健院妇产科于2018年12月-2019年12月收治的70例出现早期先兆流产症状的孕妇作为研究对象,根据不同妊娠结局分为先兆流产继续妊娠组和先兆流产妊娠失败组,每组各35例;另外选择35例健康孕妇作为健康对照组。检测所有孕妇血清AFP及β-HCG水平,并对各组血清AFP及β-HCG水平进行比较。结果先兆流产妊娠失败组的血清AFP、β-HCG水平均明显低于继续妊娠组和健康对照组〔AFP(μg/L):3.11±0.52比8.98±1.34、9.05±1.61,β-HCG(U/L):4 531.86±917.05比14230.82±4 188.88、15 240.89±4 202.91〕,差异均有统计学意义(均P<0.05);先兆流产继续妊娠组的血清AFP、β-HCG水平与健康对照组比较差异均无统计学意义(均P>0.05)。先兆流产继续妊娠组中血清AFP值≥4.79 μg/L的患者比例明显高于妊娠失败组〔85.71%(30/35)比40.00%(14/35)〕,血清β-HCG值≥5 000 U/L的患者比例也明显高于妊娠失败组〔97.14%(34/35)比48.57%(17/35)〕,差异均有统计学意义(均P<0.05)。结论血清AFP和β-HCG水平检测可有效预测孕妇早期先兆流产结局,有助于诊断早期先兆流产,值得在临床上推广应用。

Objective To explore the application of serum alpha-fetoprotein (AFP) and human chorionic gonadotropin-β (β-HCG) detection in prediction of early threatened abortion.Methods Seventy pregnant women with early threatened abortion admitted in Heze City Maternal and Child Health Care Hospital from December 2018 to December 2019 were selected.According to different pregnancy outcomes,they were divided into threatened abortion continued pregnancy group and threatened abortion pregnancy failure group,with 35 cases in each group;other 35 healthy pregnant women were selected as control group.Serum AFP and β-HCG were measured in all pregnant women and compared in each group.Results The serum AFP and β-HCG levels in the pregnancy failure group were significantly lower than those in the continuing pregnancy group and the control group [AFP (μg/L):3.11±0.52 vs.8.98±1.34,9.05±1.61,β-HCG (U/L):4 531.86±917.05 vs.14 230.82±4 188.88,15 240.89±4 202.91],and the difference was statistically significant (all P < 0.05).The serum AFP and β-HCG levels in the continued pregnancy group had no significant difference compared with the control group (both P > 0.05).In continued pregnancy group,the proportion of patients with serum AFP value ≥ 4.79 μg/L was significantly higher than that in the pregnancy failure group [85.71% (30/35) vs.40.00% (14/35)],and the proportion of patients with serum β-HCG value ≥ 5 000 U/L was also higher than that in pregnancy failure group [97.14% (34/35) vs.48.57% (17/35)],with significant difference (both P < 0.05).Conclusion The detection of serum AFP and β-HCG levels can effectively predict the outcome of early threatened abortion in pregnant women and help to diagnose early threatened abortion,which is worthy of clinical application.