七氟醚麻醉对中青年与老年结肠癌根治术患者血液流变学的影响

Influence of Sevoflurane Anesthesia on the Hemorrheology of Adultescent and Senior Patients Undergoing Radical Surgery for Colonic Cancer

为探讨七氟醚麻醉对中青年、老年结肠癌根治术患者血液流变学的影响,随机选择2017年3月至2019年3月于我院行结肠癌根治术治疗的中青年(<60岁)和老年(≥60岁)患者各30例,患者术中均采用七氟醚吸入麻醉,比较中青年患者与老年患者麻醉前(T0)、麻醉维持60 min时(T1)、麻醉结束时(T2)、进入PACU(麻醉后检测治疗室)后30 min(T3)时血液流变学指标。结果显示,从T0到T3,2组患者除红细胞变形指数和血沉方程K值变化不明显外,其他指标(高切、中切、低切全血黏度,血浆黏度,全血还原黏度,红细胞刚性指数,红细胞聚集指数)基本都是先下降,后上升。组间比较,T1时中青年组患者血浆黏度低于老年组,P<0.05;T2时,中青年组患者高切全血黏度、低切全血黏度、红细胞刚性指数明显低于老年组,P<0.05;T3时,中青年组患者高切、中切、低切全血黏度,以及血浆黏度、全血还原黏度、红细胞刚性指数、红细胞聚集指数均明显低于老年组,P<0.05。结果表明,七氟醚麻醉可有效改善结肠癌根治术患者血液高凝状态,对中青年患者的效果优于老年人。

This study was to investigate the influence of sevoflurane anesthesia on the hemorrheology of adultescent and senior patients undergoing radical surgery for colonic cancer,enrolled 60 cases of colonic cancer to be subject to surgery radical from 2017-03 to 2019-03[including 30 adultescent cases(<60 yr.)and 30 senior cases(≥60 yr.)];intraoperatively given patients sevoflurane inhalation anesthesia,then compared their hemorrheology norms at following time-points:before anesthesia(T0),anesthesia for 60 min(T1),the end of anesthesia(T2),entering PACU for 30 min(T3)between adultescent and senior patients.As results,from T0 to T3,in both groups,patients erythrodegenerative index and K value of sedimentation equation had no significant changes,other norms(including high shear,midst shear-and lowest shear-whole blood viscosity,plasma viscosity,whole blood reduced viscosity,hemagglutination index,hemorgidity index)basically fisrt declined,then uplifted,the plasma viscosity at T1 of adulteschent group was lower than that of senior group(P<0.05);at T2 in high shear,and lowest shear-whole blood viscosity,and in hemorigidity index adultescent group was significantly lower than senior group(P<0.05);at T3,in the above mentioned other norms also so did than senior group(P<0.05).Restuls show that sevoflurane anesthesia can effectively improve patients blood hypercoagulate state,in adultescent the efficacy is more superior to that in senior.