调节自噬治疗多发性骨髓瘤的研究进展

Research Progress on Regulating Autophagy in the Treatment of Multiple Myeloma--Review

自噬是真核生物中细胞对异常蛋白质、细胞器降解的过程,其对正常的细胞与肿瘤细胞的生存都有重要影响。研究表明,自噬广泛存在于骨髓瘤细胞的生命活动中,其不仅能保护骨髓瘤细胞,也能诱导其死亡,对骨髓瘤细胞的生存、增殖、侵袭与迁移以及多发性骨髓瘤的治疗起着重要的作用。本文就调节自噬水平在治疗多发性骨髓瘤中的研究进展作一综述。

Autophagy is a process in which cells in eukaryotes degrades abnormal proteins and organelles,thus it possesses important effects on the survival of normal cells and tumor cells.The related studies have shown that autophagy is widely present in the life activities of myeloma cells,which not only protects myeloma cells,but also induces death,and plays an important role in survival,proliferation,invasion and migration of myeloma cells and the treatment of multiple myeloma.This review focuses on the progress of regulating autophagy in the treatment of multiple myeloma.