非编码RNA在多发性骨髓瘤中的研究进展

Reaserch Progress on Non-Coding RNA in Multiple Myeloma--Review

研究发现,非编码RNA(non-coding RNAs,ncRNA)在多发性骨髓瘤(multiple myeloma,MM)的发生发展以及治疗中起到了重要作用。例如:某些微小RNA(microRNA,miRNA)可以调控基因表达,影响细胞自噬、凋亡等生理病理进程及蛋白质合成等,从而为MM诊断、治疗及预后评估提供依据。长链非编码RNA(long noncoding RNA,lncRNA)可以参与细胞分化,结合转录因子修饰组蛋白,特异性调控基因组等,为MM患者提供潜在的治疗靶点。而环状RNA(circular RNA,circRNA)拥有转录后调节功能,可以调节基因表达,从而抑制MM的细胞活性及细胞增殖,进一步诱导细胞凋亡。本文就不同非编码RNA的功能特征以及其在多发性骨髓瘤中的研究进展作一综述。

It is found that non-coding RNAs(ncRNA)plays an important role in the development and treatment of multiple myeloma(MM).For example,some microRNAs(miRNAs)can regulate gene expression,affect autophagy,apoptosis and other physiological and pathological processes,affect synthesis of protein,etc.,thus providing a basis for diagnosis,treatment and prognosis of MM evaluation.Long-chain non-coding RNA(Long noncoding RNA,lncRNA)can participate in cell differentiation,bind transcription factors to modify histones,specifically regulate the genome,etc.,thus providing potential therapeutic targets for MM patients.While circular RNA(CircRNA)possesses posttranscriptional regulation on function and gene expression,thereby inhibiting the cell activity and proliferation of MM,further inducing apoptosis.In this reviews the functional characteristics of different non-coding RNAs and their research progress in multiple myeloma are summarized briefly.