儿童视路胶质瘤自然消退三例并文献复习

Spontaneous regression of optic pathway glioma in children:report of three cases and review of literature

目的探讨视路胶质瘤的自然消退现象,提高对儿童视路胶质瘤的认识。方法对首都医科大学附属北京儿童医院2012年9月至2019年6月收治的3例发生自然消退的视路胶质瘤患儿的临床资料进行分析。结果3例患儿中,女性2例,男性1例,中位发病年龄为4月龄(3~5月龄),肿瘤开始消退的中位年龄为10月龄(8~13月龄),从肿瘤发病到开始消退的中位间隔时间为5个月(4~10个月)。其中1例伴有间脑综合征,1例伴有肿瘤播散转移。结论视路胶质瘤的自然消退现象多发生在婴幼儿时期,伴发间脑综合征和颅内转移播散的儿童视路胶质瘤也有肿瘤自然缩小的可能,但肿瘤缩小并不意味着症状能完全改善。

Objective To explore the phenomenon of spontaneous regression of optic pathway glioma in children,and to improve the understanding of optic pathway glioma.Methods The clinical data of 3 patients with spontaneous regression of optic pathway glioma in Beijing Children's Hospital of Capital Medical University from September 2012 to June 2019 were retrospectively analyzed.Results There were 2 girls and 1 boy among the 3 patients.The median age of onset was 4 months(3-5 months),the median age of tumor regression was 10 months(8-13 months),and the interval median time from onset to tumor regression was 5 months(4-10 months).One patient was accompanied with diencephalic syndrome,and the other was accompanied with disseminated metastasis.Conclusions The phenomenon of spontaneous regression of optic pathway glioma mostly occurs in the early childhood.Optic pathway glioma pediatric patients complicated with diencephalic syndrome or intracranial metastasis may have the possibility of tumor regression,but spontaneous regression does not mean that the symptoms can be completely improved.