新型喹唑啉类化合物的合成研究

Synthesis of Novel Quinazoline Compounds

以2-氨基-4-甲氧基-3-(3-氯丙氧基)苯甲酸甲酯为原料,经环合、氯代和取代等反应得到6种新型喹唑啉类化合物,总收率为45%左右;目标产物结构经GC-MS和核磁~1HNMR进行表征.与传统方法相比,该法具有原料廉价易得、路线简短、操作简便和反应条件温和等优点,为后续的生物活性测试打下良好的基础.

Six novel quinazolines were synthesized by the reaction of 2-amino-4-methoxy-3-( 3-chloropropoxy) benzoic acid methyl ester by cyclization,chlorination and substitution. The total yield was about 45%. The structure of target products was characterized by GC-MS and ~1HNMR. Compared with the traditional method,the method has the advantages of cheap raw materials,short route,easy operation and mild reaction conditions,which laid a good foundation for the subsequent bioactivity test.